SynthesisEmerging infectious diseases2016
Infectious Disease Risk Associated with Contaminated Propofol Anesthesia, 1989-2014(1).
Synthesis in Emerging infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Propofol and survival: an updated meta-analysis of randomized clinical trials.Critical care (London, England) · 2023Pooled it
- Sepsis outbreak following a probable extrinsic contamination of propofol by Escherichia coli, Geneva, 2024.Antimicrobial resistance and infection control · 2025Article
- Prolonged infusion of remimazolam in surgical and medical intensive care unit patients: a pilot pharmacokinetic study.Journal of intensive care · 2025Article
- Healthcare-associated bloodstream infections caused by bacterial and fungal contamination of intravenous fluids and medicines in healthcare facilities in low- and middle-income countries: a scoping review.Antimicrobial resistance and infection control · 2025Article
- Review
- Lethal Gram-negative sepsis in healthy pigs during anaesthesia with contaminated propofol.Laboratory animals · 2024Article
- Latent factors affecting safer injection practices that can reduce infections and how education can improve them.PloS one · 2024Article
- A Nontrivial Analysis of Patient Safety Risk from Parenteral Drug- and Medical Device-Borne Endotoxin.Drugs in R&D · 2023Article
- Long-term sedation with remimazolam besylate versus propofol in critically ill patients during invasive mechanical ventilation: a study protocol for a multicenter randomized non-inferior trial.Frontiers in pharmacology · 2023Article
- Article
- Propofol toxicity in the developing mouse heart mitochondria.Pediatric research · 2022Article
- Review of remimazolam and sedatives in the intensive care unit.Acute and critical care · 2022Article
- Outbreak of Sepsis Following Surgery: Utilizing 16S RNA Sequencing To Detect the Source of Infection.Cureus · 2022Article
- Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2017Article
- The Role of GABA Receptor Agonists in Anesthesia and Sedation.CNS drugs · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Administration of propofol, the most frequently used intravenous anesthetic worldwide, has been associated with several iatrogenic infections despite its relative safety. Little is known regarding the global epidemiology of propofol-related outbreaks and the effectiveness of existing preventive strategies. In this overview of the evidence of propofol as a source of infection and appraisal of preventive strategies, we identified 58 studies through a literature search in PubMed, Embase, and Lilacs for propofol-related infections during 1989-2014. Twenty propofol-related outbreaks have been reported, affecting 144 patients and resulting in 10 deaths. Related factors included reuse of syringes for multiple patients and prolonged exposure to the environment when vials were left open. The addition of antimicrobial drugs to the emulsion has been instituted in some countries, but outbreaks have still occurred. There remains a lack of comprehensive information on the effectiveness of measures to prevent future outbreaks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.