ArticlePloS one2016
Task and Resting-State fMRI Reveal Altered Salience Responses to Positive Stimuli in Patients with Major Depressive Disorder.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Social reward processing in depressed and healthy individuals across the lifespan: A systematic review and a preliminary coordinate-based meta-analysis of fMRI studies.Behavioural brain research · 2023Pooled it
- Modulating salience network connectivity through olfactory nerve stimulation.Translational psychiatry · 2025Trial
- Cognition and future depression: associations with risk in those with and without a history of depression.BMJ mental health · 2026Article
- Causal relationships between somatic movement, brain structures, and mental well-being: A multi-stage Mendelian randomization study.Psychological medicine · 2026Article
- Mapping the neurodevelopmental predictors of psychopathology.Molecular psychiatry · 2025Article
- Aberrant associations between neuronal resting-state fluctuations and working memory-induced activity in major depressive disorder.Molecular psychiatry · 2025Article
- Prenatal Exposure to Maternal Mood Entropy Is Associated With a Weakened and Inflexible Salience Network in Adolescence.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Prediction of pharmacological treatment efficacy using electroencephalography-based salience network in patients with major depressive disorder.Frontiers in psychiatry · 2024Article
- Boltzmann's Theorem Revisited: Inaccurate Time-to-Action Clocks in Affective Disorders.Current neuropharmacology · 2024Review
- Deep learning and machine learning in psychiatry: a survey of current progress in depression detection, diagnosis and treatment.Brain informatics · 2023Review
- Resting-State Functional Connectivity Impairment in Patients with Major Depressive Episode.International journal of environmental research and public health · 2022Article
- Functional MRI in major depressive disorder: A review of findings, limitations, and future prospects.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2022Review
- Prefrontal Lobe and Posterior Cingulate Cortex Activations in Patients with Major Depressive Disorder by Using Standardized Weighted Low-Resolution Electromagnetic Tomography.Journal of personalized medicine · 2021Article
- Differential Alterations in Resting State Functional Connectivity Associated with Depressive Symptoms and Early Life Adversity.Brain sciences · 2021Article
- A Novel Spectrum Contrast Mapping Method for Functional Magnetic Resonance Imaging Data Analysis.Frontiers in human neuroscience · 2021Article
- Interoceptive accuracy and its impact on neuronal responses to olfactory stimulation in the insular cortex.Human brain mapping · 2020Article
- Decreased Response to Positive Facial Affect in a Depressed Cohort in the Dorsal Striatum During a Working Memory Task-A Preliminary fMRI Study.Frontiers in psychiatry · 2019Article
- Aberrant blood-oxygen-level-dependent signal oscillations across frequency bands characterize the alcoholic brain.Addiction biology · 2018Article
- Multivariate Classification of Major Depressive Disorder Using the Effective Connectivity and Functional Connectivity.Frontiers in neuroscience · 2018Article
- Priming the Secure Attachment Schema Affects the Emotional Face Processing Bias in Attachment Anxiety: An fMRI Research.Frontiers in psychology · 2017Article
Corrections and comments
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Authors and funding
12 authors.
Funding
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Abstract
Altered brain function in patients with major depressive disorder (MDD) has been repeatedly demonstrated by task-based and resting-state studies, respectively. However, less is known concerning whether overlapped abnormalities in functional activities across modalities exist in MDD patients. To find out the answer, we implemented an fMRI experiment and collected both task and resting-state data from 19 MDD patients and 19 matched, healthy, controls. A distraction paradigm involving emotionally valenced pictures was applied to induce affective responses in subjects. As a result, concurrent deficits were found in arousing activation during a positive task in both the reward circuit and salience network (SN) that is composed of the dorsal part of anterior cingulate cortex (dACC) and bilateral anterior insulae (AI) in only the MDD group. Subsequent amplitude of low frequency fluctuations (ALFF) and functional connectivity analyses based on resting-state data exhibited consistent alterations in the bilateral AI of MDD patients, and indicated patients' difficulties in regulating the balance between central executive network (CEN) and default mode network (DMN) due to altered connectivity among the CEN, DMN, and SN. Our findings provide new evidence demonstrating impaired salience processing and resulting alterations in responses to positive stimuli in MDD patients. Furthermore, brain abnormalities synchronized across functional states in MDD patients can be evidenced by a combination of task and resting-state fMRI analyses.
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