ArticlePloS one2016
Molecular Characterization and Function Analysis of the Vitellogenin Receptor from the Cotton Bollworm, Helicoverpa armigera (Hübner) (Lepidoptera, Noctuidae).
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 49 citations in OpenAlex.
- Functional analysis of lncRNAs regulating the TOR signaling pathway and reproduction in the white-backed planthopper, Sogatella furcifera.Pest management science · 2026Article
- A novel cytochrome P450 gene, CYP12A2, regulates reproduction of Mythimna separata by modulating 20E biosynthesis.Pest management science · 2026Article
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- Metabolic profiling of baculovirus infection in Helicoverpa armigera fat body shows that Mamestra brassicae multiple nucleopolyhedrovirus promotes self-replication by increasing the synthesis of phosphatidylcholine.Archives of virology · 2025Article
- Two-way transcriptome approach for the identification of common gene targets across four insect orders and its validation in Oxycarenus laetus.Scientific reports · 2025Article
- Functional Elucidation ofInsects · 2025Article
- The vitellogenin receptor gene contributes to mating and host-searching behaviors in parasitoid wasps.iScience · 2023Article
- Integrated Analysis of MicroRNA and mRNA Expression Profiles in the Fat Bodies of MbMNPV-InfectedViruses · 2022Article
- Molecular Characterization of Vitellogenin and Its Receptor inInternational journal of molecular sciences · 2022Article
- Transcriptome analysis of sex-biased gene expression in the spotted-wing Drosophila, Drosophila suzukii (Matsumura).G3 (Bethesda, Md.) · 2022Article
- Function ofFrontiers in physiology · 2022Article
- Effects of Sublethal Concentrations of Insecticides on the Fecundity of Sogatella furcifera (Hemiptera: Delphacidae) via the Regulation of Vitellogenin and Its Receptor.Journal of insect science (Online) · 2020Article
- Heat Shock Factor Is Involved in Regulating the Transcriptional Expression of Two Potential Hsps (Frontiers in physiology · 2020Article
- Article
- Transcriptome analysis of the almond moth, Cadra cautella, female abdominal tissues and identification of reproduction control genes.BMC genomics · 2019Article
- Molecular Features and Expression Patterns of Vitellogenin Receptor in Calliptamus italicus (Orthoptera: Acrididae).Journal of insect science (Online) · 2019Article
- Molecular Characterization of Vitellogenin and Its Receptor inFrontiers in physiology · 2019Article
- Identification and Expression Patterns of Three Vitellogenin Genes and Their Roles in Reproduction of the Alligatorweed Flea BeetleFrontiers in physiology · 2019Article
- Identification and Characterization of the Vitellogenin Receptor Gene and Its Role in Reproduction in the Alligatorweed Flea Beetle,Frontiers in physiology · 2019Article
- CRISPR/Cas9-Mediated Vitellogenin Receptor Knockout Leads to Functional Deficiency in the Reproductive Development ofFrontiers in physiology · 2019Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Developing oocytes accumulate plentiful yolk protein during oogenesis through receptor-mediated endocytosis. The vitellogenin receptor (VgR), belonging to the low-density lipoprotein receptor (LDLR) family, regulates the absorption of yolk protein. In this work, the full-length vitellogenin receptor (HaVgR) in the cotton bollworm Helicoverpa armigera was identified, encoding a 1817 residue protein. Sequence alignment revealed that the sequence of HaVgR contained all of the conservative structural motifs of LDLR family members, and phylogenetic analysis indicated that HaVgR had a high identity among Lepidoptera and was distinct from that of other insects. Consistent with other insects, HaVgR was specifically expressed in ovarian tissue. The developmental expression pattern showed that HaVgR was first transcribed in the newly metamorphosed female adults, reached a peak in 2-day-old adults and then declined. Western blot analysis also revealed an ovarian-specific and developing expression pattern, which was consistent with the HaVgR mRNA transcription. Moreover, RNAi-mediated HaVgR knockdown strongly reduced the VgR expression in both the mRNA and protein levels, which inhibited the yolk protein deposition in the ovaries, led to the dramatic accumulation of vitellogenin and the up-regulation of HaVg expression in hemolymph, and eventually resulted in a declined fecundity. Together, all of these findings demonstrate that HaVgR is a specific receptor in uptake and transportation of yolk protein for the maturation of oocytes and that it plays a critical role in female reproduction.
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