ArticlePloS one2016
Triclosan Exposure Is Associated with Rapid Restructuring of the Microbiome in Adult Zebrafish.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed, 1 synthesis or guideline pooled it, 147 citations in OpenAlex.
- Pooled it
- Carboxyl Surface Modification Attenuates Polystyrene- but Not Poly(methyl methacrylate) Nanoplastic-Induced Gut Dysbiosis in Zebrafish Larvae.Environment & health (Washington, D.C.) · 2026Article
- Dietary niches drive microbial community assembly, network reorganization, and symbiont evolution in freshwater fish gut microbiomes.The ISME journal · 2026Article
- Influence of Housing, Sex, and Sampling Location on Taxonomy and Function of Adult Zebrafish Microbiomes.bioRxiv : the preprint server for biology · 2025Article
- Reversing metabolic dysregulation in farnesoid X receptor knockout mice via gut microbiota modulation.PloS one · 2025Article
- Differential gut microbiome composition in three-spined stickleback populations with contrasting levels of mercury accumulation.Frontiers in microbiology · 2025Article
- Exploration of novel bioactive compounds from the microbiome of fish and shellfish as an alternative to replace antibiotic drugs in aquaculture farming.Gut microbiome (Cambridge, England) · 2025Review
- Sampling fish gut microbiota - A genome-resolved metagenomic approach.Ecology and evolution · 2024Article
- Review
- Early Developmental Exposure to Triclosan Impacts Fecal Microbial Populations, IgA and Functional Activities of the Rat Microbiome.Journal of xenobiotics · 2024Article
- Defining the environmental determinants of dysbiosis at scale with zebrafish.Current opinion in toxicology · 2023Article
- Adverse effects of triclosan exposure on health and potential molecular mechanisms.The Science of the total environment · 2023Review
- Current knowledge on the effects of environmental contaminants in early life nutrition.Frontiers in nutrition · 2023Review
- Zebrafish: an efficient vertebrate model for understanding role of gut microbiota.Molecular medicine (Cambridge, Mass.) · 2022Review
- Application of zebrafish in the study of the gut microbiome.Animal models and experimental medicine · 2022Review
- Triclosan exposure induced disturbance of gut microbiota and exaggerated experimental colitis in mice.BMC gastroenterology · 2022Article
- Experimental methods modestly impact interpretation of the effect of environmental exposures on the larval zebrafish gut microbiome.Scientific reports · 2022Article
- Point-of-use carbon-block drinking water filters change gut microbiome of larval zebrafish.Environmental microbiology reports · 2022Article
- Draft Genome Sequence of Plesiomonas shigelloides Strain zfcc0051 (PhylumMicrobiology resource announcements · 2022Article
- Microplastic exposure across trophic levels: effects on the host-microbiota of freshwater organisms.Environmental microbiome · 2022Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Growing evidence indicates that disrupting the microbial community that comprises the intestinal tract, known as the gut microbiome, can contribute to the development or severity of disease. As a result, it is important to discern the agents responsible for microbiome disruption. While animals are frequently exposed to a diverse array of environmental chemicals, little is known about their effects on gut microbiome stability and structure. Here, we demonstrate how zebrafish can be used to glean insight into the effects of environmental chemical exposure on the structure and ecological dynamics of the gut microbiome. Specifically, we exposed forty-five adult zebrafish to triclosan-laden food for four or seven days or a control diet, and analyzed their microbial communities using 16S rRNA amplicon sequencing. Triclosan exposure was associated with rapid shifts in microbiome structure and diversity. We find evidence that several operational taxonomic units (OTUs) associated with the family Enterobacteriaceae appear to be susceptible to triclosan exposure, while OTUs associated with the genus Pseudomonas appeared to be more resilient and resistant to exposure. We also found that triclosan exposure is associated with topological alterations to microbial interaction networks and results in an overall increase in the number of negative interactions per microbe in these networks. Together these data indicate that triclosan exposure results in altered composition and ecological dynamics of microbial communities in the gut. Our work demonstrates that because zebrafish afford rapid and inexpensive interrogation of a large number of individuals, it is a useful experimental system for the discovery of the gut microbiome's interaction with environmental chemicals.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.