Evidence map›Paper›PMID 27191655›Full record

SynthesisOncotarget2016

rs965513 polymorphism as a common risk marker is associated with papillary thyroid cancer.

Fang Wang, Dehui Yan, Xu Ji, Jun Han, Meijun Chen, Hong Qiao, Shaojun Zhang

Open access · diamondAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Endocrine oncology (Bristol, England) · 2021
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Fang WangCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.
Dehui YanCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.
Xu JiDepartment of Otolaryngology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
Jun HanDepartment of Endemic Disease, the Second Affiliated Hospital, Harbin Medical University, Harbin, 150086, China.
Meijun ChenDepartment of Endemic Disease, the Second Affiliated Hospital, Harbin Medical University, Harbin, 150086, China.
Hong QiaoDepartment of Endemic Disease, the Second Affiliated Hospital, Harbin Medical University, Harbin, 150086, China.
Shaojun ZhangCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.
Harbin Medical University · CNChina Medical University · CNSecond Affiliated Hospital of Harbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Papillary thyroid cancer (PTC) is the most common type of thyroid cancer. With the rapid development of genome-wide association studies (GWAS), many genome variants associated with susceptibility to PTC have been identified, including the single nucleotide polymorphism rs965513 (9q22.33) near FOXE1. To evaluate the association between rs965513 and PTC in different ethnicities and countries, we conducted a meta-analysis using relatively large-scale samples from 23 studies (N = 163,136; 20,736 cases and 142,400 controls) by searching the PubMed and Google Scholar databases. Significant heterogeneity caused by different populations among the selected studies was observed. The A allele of rs965513 polymorphism was shown to be highly associated with risk of thyroid cancer, with odds ratios of 1.58 (95% CI 1.32-1.90) in all populations, 1.65 (95% CI 1.31-2.07)) in Caucasian populations and 1.49 in Asian populations. Compared to the dominant and recessive models, we observed the highest odds ratio (OR = 2.80, 95% CI 2.12-3.69) in the homozygous model. These results revealed that the rs965513 polymorphism is a risk factor for thyroid cancer.

Indexed as

Polymorphism, Single NucleotideAllelesBiomarkers, TumorCarcinoma, PapillaryChromosomes, Human, Pair 9Forkhead Transcription FactorsGenetic HeterogeneityGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansRisk FactorsThyroid Cancer, PapillaryThyroid NeoplasmsBiomarkers, TumorForkhead Transcription FactorsFOXE1 protein, humanFOXE1genome-wide association studiesmeta-analysisrs965513thyroid cancer

Identifiers

PMID27191655
PMCPMC5173063
OpenAlexW2362615157

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.