Cancer metabolism: Addicted to serine.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

16 citing papers in PubMed.

1. De Novo Serine Synthesis Is a Metabolic Vulnerability That Can Be Exploited to Overcome Sunitinib Resistance in Advanced Renal Cell Carcinoma.Cancer research · 2025
   Article
2. Journal of Cancer · 2024
   Article
3. Comprehensive analysis of PHGDH for predicting prognosis and immunotherapy response in patients with endometrial carcinoma.BMC medical genomics · 2023
   Article
4. Targeting HOTAIRM1 ameliorates glioblastoma by disrupting mitochondrial oxidative phosphorylation and serine metabolism.iScience · 2022
   Article
5. The intervention effect ofFrontiers in pharmacology · 2022
   Article
6. Serum Serine and the Risk of All-Cause Mortality: A Nested Case-Control Study From the China Stroke Primary Prevention Trial (CSPPT).Frontiers in nutrition · 2022
   Article
7. 3-Phosphoglycerate dehydrogenase: a potential target for cancer treatment.Cellular oncology (Dordrecht, Netherlands) · 2021
   Review
8. Prognostic value of TP53 co-mutation status combined with EGFR mutation in patients with lung adenocarcinoma.Journal of cancer research and clinical oncology · 2020
   Article
9. Oncology Therapeutics Targeting the Metabolism of Amino Acids.Cells · 2020
   Review
10. Metabolomics analysis identifies lysine and taurine as candidate prognostic biomarkers for AML-M2 patients.International journal of hematology · 2020
    Article
11. Metabolic Plasticity of Tumor Cells: How They Do Adapt to Food Deprivation.Advances in experimental medicine and biology · 2020
    Review
12. PHGDH as a mechanism for resistance in metabolically-driven cancers.Cancer drug resistance (Alhambra, Calif.) · 2020
    Article
13. Selenium Deficiency Is Associated with Pro-longevity Mechanisms.Cell reports · 2019
    Article
14. Phosphoglycerate dehydrogenase inhibition induces p-mTOR-independent autophagy and promotes multilineage differentiation in embryonal carcinoma stem-like cells.Cell death & disease · 2018
    Article
15. PHGDH as a Key Enzyme for Serine Biosynthesis in HIF2α-Targeting Therapy for Renal Cell Carcinoma.Cancer research · 2017
    Article
16. The Central Role of Amino Acids in Cancer Redox Homeostasis: Vulnerability Points of the Cancer Redox Code.Frontiers in oncology · 2017
    Review

Corrections and comments

• Comment on
  A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.2016

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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