Evidence map›Paper›PMID 27191599›Full record

ArticleOrganic letters2016

Photochemical Generation of Benzyl Cations That Selectively Cross-Link Guanine and Cytosine in DNA.

Yibin Wang, Shuo Liu, Zechao Lin, Yukai Fan, Yinsheng Wang, Xiaohua Peng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yibin WangDepartment of Chemistry and Biochemistry and Milwaukee Institute of Drug Discovery, University of Wisconsin Milwaukee , 3210 North Cramer Street, Milwaukee, Wisconsin 53211, United States.
Shuo LiuDepartment of Chemistry, University of California Riverside , 501 Big Springs Road, Riverside, California 92521-0403, United States.
Zechao LinDepartment of Chemistry and Biochemistry and Milwaukee Institute of Drug Discovery, University of Wisconsin Milwaukee , 3210 North Cramer Street, Milwaukee, Wisconsin 53211, United States.
Yukai FanDepartment of Chemistry and Biochemistry and Milwaukee Institute of Drug Discovery, University of Wisconsin Milwaukee , 3210 North Cramer Street, Milwaukee, Wisconsin 53211, United States.
Yinsheng WangDepartment of Chemistry, University of California Riverside , 501 Big Springs Road, Riverside, California 92521-0403, United States.
Xiaohua PengDepartment of Chemistry and Biochemistry and Milwaukee Institute of Drug Discovery, University of Wisconsin Milwaukee , 3210 North Cramer Street, Milwaukee, Wisconsin 53211, United States.

Funding

Repair of Radiation-Induced Crosslink Lesions of DNAR01ES019873 · NIEHS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI WANG, YINSHENG · 2012 to 2016
$1.5M
New Radiation-Activated Antitumor Agents That Target HypoxiaR15CA152914 · NCI · UNIVERSITY OF WISCONSIN MILWAUKEE · PI PENG, XIAOHUA · 2010 to 2010
$359k
NCI NIH HHS R15 CA152914NIEHS NIH HHS R01 ES019873
6 · The paper itself

Abstract

UV irradiation of several aryl boronates efficiently produced bifunctional benzyl cations that selectively form guanine-cytosine cross-links in DNA. Photoinduced homolysis of the C-Br bond took place with the aryl boronate bromides 3a and 4a, generating free radicals that were oxidized to benzyl cations via electron transfer. However, photoirradiation of the quaternary ammonium salts 3b and 4b led to heterolysis of C-N bond, directly producing benzyl cations. The electron-donating group in the aromatic ring greatly enhanced cross-linking efficiency.

Indexed as

Base SequenceBenzene DerivativesBoronic AcidsCationsCross-Linking ReagentsCyclic N-OxidesCytosineDNADNA AdductsGuanineHydroxylaminesOxidation-ReductionPhotochemical ProcessesBenzene DerivativesBoronic AcidsCationsCross-Linking ReagentsCyclic N-OxidesCytosineDNADNA AdductsGuanineHydroxylaminesmethoxyamineTEMPO

Identifiers

PMID27191599
PMCPMC5609456

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.