Evidence map›Paper›PMID 27191188›Full record

ArticleEmerging infectious diseases2016

Development of Medical Countermeasures to Middle East Respiratory Syndrome Coronavirus.

Timothy M Uyeki, Karl J Erlandson, George Korch, Michael O'Hara, Michael Wathen, Jean Hu-Primmer, Sally Hojvat, Erik J Stemmy, Armen Donabedian

Open access · diamondAbstract read
In one paragraph

Article in Emerging infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
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  6. Core Minimal Datasets to Advance Clinical Research for Priority Epidemic Diseases.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
    Article
  7. Systems Biology Approaches for Therapeutics Development Against COVID-19.Frontiers in cellular and infection microbiology · 2020
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Offering patients more: how the West Africa Ebola outbreak can shape innovation in therapeutic research for emerging and epidemic infections.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017
    Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Taking forward a 'One Health' approach for turning the tide against the Middle East respiratory syndrome coronavirus and other zoonotic pathogens with epidemic potential.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Timothy M Uyeki
Karl J Erlandson
George Korch
Michael O'Hara
Michael Wathen
Jean Hu-Primmer
Sally Hojvat
Erik J Stemmy
Armen Donabedian
Centers for Disease Control and Prevention · USUnited States Food and Drug Administration · USNational Institutes of Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preclinical development of and research on potential Middle East respiratory syndrome coronavirus (MERS-CoV) medical countermeasures remain preliminary; advancements are needed before most countermeasures are ready to be tested in human clinical trials. Research priorities include standardization of animal models and virus stocks for studying disease pathogenesis and efficacy of medical countermeasures; development of MERS-CoV diagnostics; improved access to nonhuman primates to support preclinical research; studies to better understand and control MERS-CoV disease, including vaccination studies in camels; and development of a standardized clinical trial protocol. Partnering with clinical trial networks in affected countries to evaluate safety and efficacy of investigational therapeutics will strengthen efforts to identify successful medical countermeasures.

Indexed as

Disease Models, AnimalMiddle East Respiratory Syndrome CoronavirusAnimalsCamelusCoronavirus InfectionsHumansViral VaccinesViral Vaccinesanimal modelsantibodiesantiviralsdiagnosticsmedical countermeasuresMERS-CoVMiddle East respiratory syndrome coronavirusmonoclonalnon-human primatesnonhuman primatespolyclonalrespiratory infectionstherapeuticsvaccinesviruses

Identifiers

PMID27191188
PMCPMC4918159
OpenAlexW2400098676

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.