ArticleJournal of diabetes research2016
Heart Rate Variability as Early Biomarker for the Evaluation of Diabetes Mellitus Progress.
Article in Journal of diabetes research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Sexual Dimorphism in the Development of Cardiometabolic Syndrome.Handbook of experimental pharmacology · 2026Review
- Can heart rate variability demonstrate the effects and the levels of mindfulness? A repeated-measures study on experienced and novice mindfulness practitioners.BMC complementary medicine and therapies · 2025Article
- Electrodiagnostic assessment of autonomic nervous system in diabetic autonomic neuropathy: Case series in 72 diabetes patients.Journal of family medicine and primary care · 2025Article
- A maternal diet high in carbohydrates causes bradyarrhythmias and changes in heart rate variability in the offspring sex-dependent in mice.Laboratory animal research · 2024Article
- Ventricular Dysfunction in Obese and Nonobese Rats with Metabolic Syndrome.Journal of diabetes research · 2022Article
- Moving average and standard deviation thresholding (MAST): a novel algorithm for accurate R-wave detection in the murine electrocardiogram.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2021Article
- Accurate assessment of LV function using the first automated 2D-border detection algorithm for small animals - evaluation and application to models of LV dysfunction.Cardiovascular ultrasound · 2019Article
- Effects of smoking status, history and intensity on heart rate variability in the general population: The CHRIS study.PloS one · 2019Article
- The Role of the Autonomic Nervous System on Cardiac Rhythm during the Evolution of Diabetes Mellitus Using Heart Rate Variability as a Biomarker.Journal of diabetes research · 2019Article
- Ultra-short heart rate variability recording reliability: The effect of controlled paced breathing.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2018Article
- Effects of Coexistence Hypertension and Type II Diabetes on Heart Rate Variability and Cardiorespiratory Fitness.Arquivos brasileiros de cardiologia · 2018Article
- Taking Systems Medicine to Heart.Circulation research · 2018Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
According to the American Diabetes Association (ADA), the side effects of diabetes mellitus have recently increased the global health expenditure each year. Of these, the early diagnostic can contribute to the decrease on renal, cardiovascular, and nervous systems complications. However, the diagnostic criteria, which are commonly used, do not suggest the diabetes progress in the patient. In this study, the streptozotocin model in mice (cDM) was used as early diagnostic criterion to reduce the side effects related to the illness. The results showed some clinical signs similarly to five-year diabetes progress without renal injury, neuropathies, and cardiac neuropathy autonomic in the cDM-model. On the other hand, the electrocardiogram was used to determine alterations in heart rate and heart rate variability (HRV), using the Poincaré plot to quantify the HRV decrease in the cDM-model. Additionally, the SD1/SD2 ratio and ventricular arrhythmias showed increase without side effects of diabetes. Therefore, the use of HRV as an early biomarker contributes to evaluating diabetes mellitus complications from the diagnostic.
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