Evidence map›Paper›PMID 27190764›Full record

ArticleQuantitative imaging in medicine and surgery2016

Optic nerve head perfusion in normal eyes and eyes with glaucoma using optical coherence tomography-based microangiography.

Chieh-Li Chen, Karine D Bojikian, Divakar Gupta, Joanne C Wen, Qinqin Zhang, Chen Xin, Rei Kono, Raghu C Mudumbai, Murray A Johnstone, Philip P Chen and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Quantitative imaging in medicine and surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 73 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Optic nerve head injury and optical coherence tomography angiography.Quantitative imaging in medicine and surgery · 2021
    Article
  10. Optical Coherence Tomography and Glaucoma.Annual review of vision science · 2021
    Review
  11. Non-invasive detection of intracranial pressure related to the optic nerve.Quantitative imaging in medicine and surgery · 2021
    Review
  12. Article
  13. Imaging video plethysmography shows reduced signal amplitude in glaucoma patients in the area of the microvascular tissue of the optic nerve head.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021
    Article
  14. Article
  15. Article
  16. Optical coherence tomography angiography in glaucoma.Annals of translational medicine · 2020
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Chieh-Li Chen1 Department of Bioengineering, 2 Department of Ophthalmology, University of Washington, Seattle, WA, USA ; 3 Department of Ophthalmology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
Karine D Bojikian1 Department of Bioengineering, 2 Department of Ophthalmology, University of Washington, Seattle, WA, USA ; 3 Department of Ophthalmology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
Divakar Gupta1 Department of Bioengineering, 2 Department of Ophthalmology, University of Washington, Seattle, WA, USA ; 3 Department of Ophthalmology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
Joanne C Wen1 Department of Bioengineering, 2 Department of Ophthalmology, University of Washington, Seattle, WA, USA ; 3 Department of Ophthalmology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
Qinqin Zhang1 Department of Bioengineering, 2 Department of Ophthalmology, University of Washington, Seattle, WA, USA ; 3 Department of Ophthalmology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
Chen Xin1 Department of Bioengineering, 2 Department of Ophthalmology, University of Washington, Seattle, WA, USA ; 3 Department of Ophthalmology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
Rei Kono1 Department of Bioengineering, 2 Department of Ophthalmology, University of Washington, Seattle, WA, USA ; 3 Department of Ophthalmology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
Raghu C Mudumbai1 Department of Bioengineering, 2 Department of Ophthalmology, University of Washington, Seattle, WA, USA ; 3 Department of Ophthalmology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
Murray A Johnstone1 Department of Bioengineering, 2 Department of Ophthalmology, University of Washington, Seattle, WA, USA ; 3 Department of Ophthalmology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
Philip P Chen1 Department of Bioengineering, 2 Department of Ophthalmology, University of Washington, Seattle, WA, USA ; 3 Department of Ophthalmology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
Ruikang K Wang1 Department of Bioengineering, 2 Department of Ophthalmology, University of Washington, Seattle, WA, USA ; 3 Department of Ophthalmology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
University of Washington · USBeijing Anzhen Hospital · CNCapital Medical University · CN

Funding

NON-INVASIVE REAL-TIME LABEL-FREE 3D IMAGING OF RETINAL MICROCIRCULATIONR01EY024158 · NEI · UNIVERSITY OF WASHINGTON · PI WANG, RUIKANG · 2014 to 2017
$1.7M
NEI NIH HHS R01 EY024158
6 · The paper itself

Abstract

backgroundTo investigate the differences of perfusion in the optic nerve head (ONH) between normal and glaucomatous eyes using optical microangiography (OMAG) based optical coherence tomography (OCT) angiography technique.

methodsOne eye from each subject was scanned with a 68 kHz Cirrus 5000 HD-OCT-based OMAG prototype system centered at the ONH (Carl Zeiss Meditec Inc, Dublin, CA, USA). Microvascular images were generated from the OMAG dataset by detecting the differences in OCT signal between consecutive B-scans. The pre-laminar layer (preLC) was isolated by a semi-automatic segmentation program. En face OMAG images for preLC were generated using signals with highest blood flow signal intensity. ONH perfusion was quantified as flux, vessel area density, and normalized flux within the ONH. Standard t-tests were performed to analyze the ONH perfusion differences between normal and glaucomatous eyes. Linear regression models were constructed to analyze the correlation between ONH perfusion and other clinical measurements.

resultsTwenty normal and 21 glaucoma subjects were enrolled. Glaucomatous eyes had significantly lower ONH perfusion in preLC in all three perfusion metrics compared to normal eyes (P≤0.0003). Significant correlations between ONH perfusion and disease severity as well as structural changes were detected in glaucomatous eyes (P≤0.012).

conclusionsONH perfusion detected by OMAG showed significant differences between glaucoma and normal controls and was significantly correlated with disease severity and structural defects in glaucomatous eyes. ONH perfusion measurement using OMAG may provide useful information for detection and monitoring of glaucoma.

Indexed as

Optical coherence tomography angiographyoptical microangiography (OMAG)optic nerve head perfusionprimary open-angle glaucoma (POAG)

Identifiers

PMID27190764
PMCPMC4858460
OpenAlexW2309740240

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.