Evidence map›Paper›PMID 27190640›Full record

ArticleJournal of ophthalmology2016

Comparison of the Efficacy of Intravitreal Aflibercept and Bevacizumab for Macular Edema Secondary to Branch Retinal Vein Occlusion.

Jia-Kang Wang, Pei-Yuan Su, Yung-Ray Hsu, Yun-Ju Chen, Fang-Ting Chen, Ying-Yu Tseng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ophthalmology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Adjunctive topical bromfenac and the 3-year bevacizumab injection burden in macular edema secondary to branch retinal vein occlusion.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jia-Kang WangDepartment of Ophthalmology, Far Eastern Memorial Hospital, No. 21, Section 2, Nan-Ya South Road, Pan-Chiao District, New Taipei City 220, Taiwan; Department of Medicine, National Yang Ming University, Taipei City, Taiwan; Department of Healthcare Administration and Department of Nursing, Oriental Institute of Technology, New Taipei City 220, Taiwan; Department of Medicine, National Taiwan University, Taipei City, Taiwan; Department of Electrical Engineering, Yuan Ze University, Taiwan.
Pei-Yuan SuDepartment of Ophthalmology, Far Eastern Memorial Hospital, No. 21, Section 2, Nan-Ya South Road, Pan-Chiao District, New Taipei City 220, Taiwan; Department of Medicine, National Taiwan University, Taipei City, Taiwan; Department of Medicine, Fu Jen Catholic University, New Taipei City 220, Taiwan.
Yung-Ray HsuDepartment of Ophthalmology, Far Eastern Memorial Hospital, No. 21, Section 2, Nan-Ya South Road, Pan-Chiao District, New Taipei City 220, Taiwan; Department of Medicine, National Taiwan University, Taipei City, Taiwan.
Yun-Ju ChenDepartment of Ophthalmology, Far Eastern Memorial Hospital, No. 21, Section 2, Nan-Ya South Road, Pan-Chiao District, New Taipei City 220, Taiwan; Department of Medicine, National Taiwan University, Taipei City, Taiwan.
Fang-Ting ChenDepartment of Ophthalmology, Far Eastern Memorial Hospital, No. 21, Section 2, Nan-Ya South Road, Pan-Chiao District, New Taipei City 220, Taiwan; Department of Medicine, National Taiwan University, Taipei City, Taiwan.
Ying-Yu TsengDepartment of Ophthalmology, Far Eastern Memorial Hospital, No. 21, Section 2, Nan-Ya South Road, Pan-Chiao District, New Taipei City 220, Taiwan; Department of Medicine, China Medical University, Taichung City, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fifty-two eyes of 52 patients with treatment-naïve macular edema associated with perfused branch retinal vein occlusion were retrospectively reviewed. Twenty-seven cases received PRN intravitreal bevacizumab, and 25 cases were treated by PRN intravitreal aflibercept with monthly follow-ups for 12 months. Both aflibercept and bevacizumab were effective in reduction of macular thickness and improvement of visual acuity for the participants. Both antivascular endothelial growth factor agents had similar efficacy and duration of treatment for these eyes with macular edema secondary to branch retinal vein occlusion during a 12-month period. No serious systemic or ocular adverse events were reported.

Identifiers

PMID27190640
PMCPMC4844878

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.