ArticleJournal of ophthalmology2016
Repeatability and Reproducibility of Noninvasive Keratograph 5M Measurements in Patients with Dry Eye Disease.
Article in Journal of ophthalmology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04608942 (Plasma Jet Approach for Refractory Meibomian Gland Dysfunction Patients), which is not on this map. Cited by 80 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Plasma Jet Approach for Refractory Meibomian Gland Dysfunction Patients
Who cites it
80 citing papers in PubMed, 178 citations in OpenAlex.
- Comparing automated and manual assessments of tear break-up time using different non-invasive devices and a fluorescein procedure.Scientific reports · 2024Trial
- Effect of a single warm compress prior to ophthalmic surgery on ocular surface and intraoperative visibility: a randomised controlled study.BMJ open ophthalmology · 2023Trial
- Use of Artificial Tears in Patients Undergoing Treatment with Anti-VEGF Intravitreal Injections.Clinical ophthalmology (Auckland, N.Z.) · 2022Trial
- Comparison of efficacy of trehalose-based eye drops versus topical 0.1% Hyaluronic Acid for management of clinically significant dry eye using non-invasive investigational modalities.International ophthalmology · 2021Trial
- Trial
- Trial
- Ocular Surface Symptoms, Objective Redness, and Intraocular Pressure After a Switch from Fixed Dorzolamide/Timolol to Netarsudil in Latanoprost-Treated Glaucoma and Ocular Hypertension: A Prospective Real-World Cohort Study.Medicina (Kaunas, Lithuania) · 2026Observational
- Benchmarking Statistical, Machine Learning, and Exploratory Deep Learning Models for the Short-Term Forecasting of Monthly Aggregated Adult Ocular Surface Indicators: An Exploratory Hospital-Level Study.Diagnostics (Basel, Switzerland) · 2026Article
- Analytical Performance, Spatial Dynamics and Clinically Meaningful Change Thresholds for Automated Non-invasive Tear Film Assessment Using the Oculus Keratograph 5M.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Dry Eye in Colombian Tomato Farmers: An Exploratory Cross-Sectional Study of Occupational Exposure Duration.Journal of personalized medicine · 2026Article
- Tear Clearance Rate Assessment with a Modified Slit Lamp Biomicroscope.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Light Discomfort Thresholds in Patients with Moderate-to-Severe Active versus Mild Non-Active Thyroid Eye Disease.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Dry Eye Disease And The Jenvis Dry Eye Report Diagnosis Tool: A Literature Review with Emphasis On African Populations.Clinical optometry · 2026Review
- Article
- Association of the glucose metabolism continuum (fasting plasma glucose/HbA1c) with tear-film stability and secretion: ocular surface evidence across non-diabetes, prediabetes, and diabetes.Frontiers in endocrinology · 2026Article
- Multicentre Pixel-Level Tear Meniscus Segmentation Dataset with Multimodal Imaging for Dry Eye Diagnosis.Scientific data · 2025Article
- The Impact of Dry Eye Disease on Corneal Biomechanics Analyzed with Corneal Visualization Scheimpflug Technology.Biomedicines · 2025Article
- The Impact of 3% Diquafosol Ophthalmic Solution on Tear Film and Corneal Nerve Density in Patients with Diabetes and Dry Eye Disease: A Randomized Controlled Study.Ophthalmology and therapy · 2025Article
- Light discomfort thresholds under different lighting conditions in healthy subjects and dry eye patients.Scientific reports · 2025Article
- Advancing Diagnostics with Semi-Automatic Tear Meniscus Central Area Measurement for Aqueous Deficient Dry Eye Discrimination.Medicina (Kaunas, Lithuania) · 2025Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose. To determine the intraexaminer repeatability and interexaminer reproducibility of tear meniscus height (TMH) and noninvasive Keratograph tear breakup time (NIKBUT) measurements obtained with the Keratograph 5M (K5M) in a sample of healthy and dry eye populations. Methods. Forty-two patients with dry eye disease (DED group) and 42 healthy subjects (healthy group) were recruited in this prospective study. In all subjects, each eye received 3 consecutive measurements using the K5M for the TMH and NIKBUTs (NIKBUT-first and NIKBUT-average). And then a different examiner repeated the measurements. The repeatability and reproducibility of measurements were assessed by the coefficient of variation (CV) and intraclass correlation coefficient (ICC). Results. The repeatability and reproducibility of TMH and NIKBUTs were good in both DED and healthy groups (CV% ≤ 26.1% and ICC ≥ 0.75 for all measurements). Patients with DED showed better intraexaminer repeatability for NIKBUTs, but worse for TMH than healthy subjects. Average TMH, NIKBUT-first, and NIKBUT-average were significantly lower in DED group than in healthy group (all P values < 0.05). Conclusions. Measurements of TMH and NIKBUTs obtained with the K5M may provide a simple, noninvasive screening test for dry eye with acceptable repeatability and reproducibility. The NIKBUTs were more reliable, but TMH was less reliable in patients with DED.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.