Evidence map›Paper›PMID 27190597›Full record

ArticleACS medicinal chemistry letters2016

Autoradiographic Evaluation of [(18)F]FECUMI-101, a High Affinity 5-HT1AR Ligand in Human Brain.

J S Dileep Kumar, Mark D Underwood, Norman R Simpson, Suham A Kassir, Jaya Prabhakaran, Vattoly J Majo, Mihran J Bakalian, Ramin V Parsey, J John Mann, Victoria Arango

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Radiotracers for the Central Serotoninergic System.Pharmaceuticals (Basel, Switzerland) · 2022
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

J S Dileep KumarDivision of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, New York 10032, United States; Department of Psychiatry, Stony Brook University School of Medicine, Stony Brook, New York 11794, United States.
Mark D UnderwoodDivision of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, New York 10032, United States; Department of Psychiatry, Columbia University Medical Center, New York, New York 10032, United States.
Norman R SimpsonDivision of Molecular Imaging and Neuropathology, New York State Psychiatric Institute , New York, New York 10032, United States.
Suham A KassirDivision of Molecular Imaging and Neuropathology, New York State Psychiatric Institute , New York, New York 10032, United States.
Jaya PrabhakaranDepartment of Psychiatry, Columbia University Medical Center , New York, New York 10032, United States.
Vattoly J MajoDepartment of Psychiatry, Columbia University Medical Center , New York, New York 10032, United States.
Mihran J BakalianDivision of Molecular Imaging and Neuropathology, New York State Psychiatric Institute , New York, New York 10032, United States.
Ramin V ParseyDepartment of Psychiatry, Stony Brook University School of Medicine , Stony Brook, New York 11794, United States.
J John MannDivision of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, New York 10032, United States; Department of Psychiatry, Columbia University Medical Center, New York, New York 10032, United States.
Victoria ArangoDivision of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, New York 10032, United States; Department of Psychiatry, Columbia University Medical Center, New York, New York 10032, United States.
New York Psychoanalytic Society and Institute · USColumbia University Irving Medical Center · USStony Brook University · US

Funding

Suicidal Behavior: Aggression Subtypes, Childhood Adversity and Stress ResponseP50MH090964 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI MANN, JOSEPH JOHN · 2013 to 2022
$23.6M
THE NEUROBIOLOGY OF SUICIDAL BEHAVIORP50MH062185 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI MANN, JOSEPH JOHN · 2000 to 2009
$21.7M
POSTMORTEM NEUROCHEMICAL STUDIES IN SUICIDER01MH040210 · NIMH · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI UNDERWOOD, MARK D · 1985 to 2016
$7.0M
NIMH NIH HHS P50 MH062185NIMH NIH HHS P50 MH090964NIMH NIH HHS R01 MH040210
6 · The paper itself

Abstract

[(18)F]FECUMI-101 ([(18)F]1) is a 5HT1AR ligand demonstrating specific binding in brain regions corresponding to the distribution of 5-HT1AR in baboons. However, we detected moderate uptake of [(18)F]1 in baboon thalamus, a brain region lacking 5-HT1AR. We sought to investigate the relative binding of [(18)F]1 to 5-HT1AR, α1R, and 5-HT7R in vitro. Using autoradiography in human brain sections, specific binding of [(18)F]1 to 5-HT1AR was confirmed. However, [(18)F]1 also showed 26% binding to α1R in PFC. The hippocampal formation exhibited 51% and 92% binding of [(18)F]1 to α1R and 5-HT1AR, respectively. Thalamus and cerebellum showed very little binding. There is no measurable specific binding of [(18)F]1 to 5-HT7R and no effect of temperature on [(18)F]1 specific binding to 5-HT1AR or α1R. These results indicate that, while [(18)F]FECUMI-101 is not a completely selective 5-HT1AR ligand for receptor quantification, it may be useful for occupancy measurements of drugs acting at 5-HT1AR in vivo.

Indexed as

5-HT1ARautoradiographyhippocampusPETradiotracerα1R

Identifiers

PMID27190597
PMCPMC4867482
OpenAlexW2296191394

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.