Evidence map›Paper›PMID 27190585›Full record

ReviewWorld journal of gastrointestinal oncology2016

Urinary metabolites as noninvasive biomarkers of gastrointestinal diseases: A clinical review.

Irene Sarosiek, Rudolf Schicho, Pedro Blandon, Mohammad Bashashati

Registry-linked trialAbstract readReview
In one paragraph

Review in World journal of gastrointestinal oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03107819 (Plasma and Urine Metabolomics for Biomarker Discovery in Children With Eosinophilic Esophagitis), which is not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03107819 completednot on this mapstarted 2017, after this paper: background citation

Plasma and Urine Metabolomics for Biomarker Discovery in Children With Eosinophilic Esophagitis

TypeobservationalSponsorThe University of Texas Health Science Center, HoustonRan2017 to 2018Enrolled24ConditionsEosinophilic EsophagitisArmsPlasma and urine metabolomics
3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Irene SarosiekIrene Sarosiek, Mohammad Bashashati, Division of Gastroenterology, Department of Internal Medicine, Texas Tech University Health Sciences Center, El Paso, TX 79905, United States.
Rudolf SchichoIrene Sarosiek, Mohammad Bashashati, Division of Gastroenterology, Department of Internal Medicine, Texas Tech University Health Sciences Center, El Paso, TX 79905, United States.
Pedro BlandonIrene Sarosiek, Mohammad Bashashati, Division of Gastroenterology, Department of Internal Medicine, Texas Tech University Health Sciences Center, El Paso, TX 79905, United States.
Mohammad BashashatiIrene Sarosiek, Mohammad Bashashati, Division of Gastroenterology, Department of Internal Medicine, Texas Tech University Health Sciences Center, El Paso, TX 79905, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The diagnosis of gastrointestinal (GI) disorders is usually based on invasive techniques such as endoscopy. A key important factor in GI cancer is early diagnosis which warrants development of non- or less-invasive diagnostic techniques. In addition, monitoring and surveillance are other important parts in the management of GI diseases. Metabolomics studies with nuclear magnetic resonance and mass spectrometry can measure the concentration of more than 3000 chemical compounds in the urine providing possible chemical signature in different diseases and during health. In this review, we discuss the urinary metabolomics signature of different GI diseases including GI cancer and elaborate on how these biomarkers could be used for the classification, early diagnosis and the monitoring of the patients. Moreover, we discuss future directions of this still evolving field of research.

Indexed as

CancerGastrointestinal diseasesInflammatory bowel diseaseMetabolomeMetabolomicsUrine

Identifiers

PMID27190585
PMCPMC4865713

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.