Evidence map›Paper›PMID 27190516›Full record

ArticleInternational journal of dentistry2016

Minimally Invasive Alveolar Ridge Preservation Utilizing an In Situ Hardening β-Tricalcium Phosphate Bone Substitute: A Multicenter Case Series.

Minas D Leventis, Peter Fairbairn, Ashish Kakar, Angelos D Leventis, Vasileios Margaritis, Walter Lückerath, Robert A Horowitz, Bappanadu H Rao, Annette Lindner, Heiner Nagursky

Abstract read
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In one paragraph

Article in International journal of dentistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Review
  2. Article
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  5. Review
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  9. Overview of Antimicrobial Biodegradable Polyester-Based Formulations.International journal of molecular sciences · 2023
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. [Recent research advances on alveolar ridge preservation after tooth extraction].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2019
    Article
  17. Article
  18. Evaluation of an In Situ HardeningDentistry journal · 2018
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Minas D LeventisDepartment of Oral and Maxillofacial Surgery, Dental School, University of Athens, 2 Thivon Street, Goudi, 115 27 Athens, Greece.
Peter FairbairnDepartment of Periodontology and Implant Dentistry, School of Dentistry, University of Detroit Mercy, 2700 Martin Luther King Jr Boulevard, Detroit, MI 48208, USA.
Ashish KakarDental College, Yenepoya University, University Road, Mangalore, Karnataka 575018, India.
Angelos D LeventisMedical School, University of Athens, 75 M. Assias Street, 115 27 Athens, Greece.
Vasileios MargaritisPhD and DrPH Public Health Programs, College of Health Sciences, Walden University, 100 S Washington Avenue No. 900, Minneapolis, MN 55401, USA.
Walter LückerathDepartment of Prosthodontics, Preclinical Education and Materials Science, University of Bonn, Regina-Pacis-Weg 3, 53113 Bonn, Germany.
Robert A HorowitzDepartments of Periodontics, Implant Dentistry, and Oral Surgery, New York University College of Dentistry, 345 E. 24th Street, New York, NY 10010, USA.
Bappanadu H RaoDental College, Yenepoya University, University Road, Mangalore, Karnataka 575018, India.
Annette LindnerDepartment for Oral and Maxillofacial Surgery, Cell Tissue Analysis (CTA), Medical Center, University of Freiburg, Hugstetter Street 55, 79106 Freiburg, Germany.
Heiner NagurskyInstitute for Clinical Chemistry and Laboratory Medicine, Medical Center, University of Freiburg, Hugstetter Street 55, 79106 Freiburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ridge preservation measures, which include the filling of extraction sockets with bone substitutes, have been shown to reduce ridge resorption, while methods that do not require primary soft tissue closure minimize patient morbidity and decrease surgical time and cost. In a case series of 10 patients requiring single extraction, in situ hardening beta-tricalcium phosphate (β-TCP) granules coated with poly(lactic-co-glycolic acid) (PLGA) were utilized as a grafting material that does not necessitate primary wound closure. After 4 months, clinical observations revealed excellent soft tissue healing without loss of attached gingiva in all cases. At reentry for implant placement, bone core biopsies were obtained and primary implant stability was measured by final seating torque and resonance frequency analysis. Histological and histomorphometrical analysis revealed pronounced bone regeneration (24.4 ± 7.9% new bone) in parallel to the resorption of the grafting material (12.9 ± 7.7% graft material) while high levels of primary implant stability were recorded. Within the limits of this case series, the results suggest that β-TCP coated with polylactide can support new bone formation at postextraction sockets, while the properties of the material improve the handling and produce a stable and porous bone substitute scaffold in situ, facilitating the application of noninvasive surgical techniques.

Identifiers

PMID27190516
PMCPMC4848413

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.