Trial reportNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2017
The natural history of immunoglobulin M nephropathy in adults.
Trial report in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Glomerulonephritis in Takayasu arteritis is dominated by mesangial and AA amyloid lesions and often arises during remission: a case-based review.Rheumatology international · 2026Pooled it
- IgM nephropathy is a controversial entity: a distinct nephropathy or part of the podocytopathy spectrum? A systematic review of the literature.BMC nephrology · 2026Pooled it
- Article
- Comparison between characteristics of immunoglobulin M nephropathy and other glomerular diseases.Kidney research and clinical practice · 2025Article
- Clinical Characteristics and Renal Outcomes in Patients with IgM Nephropathy: A Retrospective Single-Center Study.International journal of general medicine · 2025Article
- Immunoglobulin M nephropathy: requiring more attention.Kidney research and clinical practice · 2025Article
- Pathological and Evolutive Correlations in Steroid Resistant Nephrotic Syndrome in Children.International journal of general medicine · 2022Article
- Article
- Renal Outcome of IgM Nephropathy: A Comparative Prospective Cohort Study.Journal of clinical medicine · 2021Article
- Late relapse of IgM nephropathy-associated nephrotic syndrome after repeated administration of immune checkpoint inhibitor against pulmonary adenocarcinoma.Clinical case reports · 2021Article
- IgM nephropathy complicated by cerebral venous sinus thrombosis: a case study.BMC nephrology · 2020Article
- Epidemiology and Pathophysiology of Glomerular C4d Staining in Native Kidney Biopsies.Kidney international reports · 2019Article
- Article
- A case report of immunoglobulin M nephropathy manifesting as crescentic glomerulonephritis and nephrotic syndrome in an adult.BMC nephrology · 2019Article
- Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundImmunoglobulin M (IgM) nephropathy is an idiopathic glomerulonephritis characterized by diffuse mesangial deposition of IgM. IgM nephropathy has been a controversial diagnosis since it was first reported, and there are few data identifying specific pathological features that predict the risk of progression of renal disease.
methodsWe identified 57 cases of IgM nephropathy among 3220 adults undergoing renal biopsy at our institution. Biopsies had to satisfy the following three criteria to meet the definition of IgM nephropathy in this study: (i) dominant mesangial staining for IgM, (ii) mesangial deposits on electron microscopy (EM) and (iii) exclusion of systemic disease.
resultsThe median age was 42 years and 24 patients were male. Thirty-nine per cent of patients presented with the nephrotic syndrome, 49% presented with non-nephrotic proteinuria and 39% had eGFR <60 mL/min. The median post-biopsy follow-up was 40 months and serum creatinine had doubled in 31% by 5 years. Of histological parameters, glomerular sclerosis and tubular atrophy, but not mesangial proliferation, were risk factors for renal insufficiency. Thirty-nine per cent of nephrotic patients achieved complete remission, and outcome was significantly worse in those who did not respond to treatment. Focal segmental glomerulosclerosis was diagnosed in 80% of those undergoing repeat renal biopsy, despite ongoing mesangial IgM deposition.
conclusionsWe propose criteria for a consensus definition of IgM nephropathy.
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