ArticleSchizophrenia bulletin2016
Predictive Motor Timing and the Cerebellar Vermis in Schizophrenia: An fMRI Study.
Article in Schizophrenia bulletin, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Bridging the gap between aberrant time processing and cognitive dysfunction in schizophrenia: a potential core feature?Schizophrenia (Heidelberg, Germany) · 2025Review
- Cerebellar transcranial magnetic stimulation in psychotic disorders: intermittent, continuous, and sham theta-burst stimulation on time perception and symptom severity.Frontiers in psychiatry · 2023Article
- Time discrimination and change detection could share a common brain network: findings of a task-based fMRI study.Frontiers in psychology · 2023Article
- Detecting abnormal connectivity in schizophrenia via a joint directed acyclic graph estimation model.NeuroImage · 2022Article
- Functional Alterations in Cerebellar Functional Connectivity in Anxiety Disorders.Cerebellum (London, England) · 2021Article
- Quantitative but Not Qualitative Performance Changes in Predictive Motor Timing as a Result of Overtraining.Cerebellum (London, England) · 2020Article
- Neural Scaffolding as the Foundation for Stable Performance of Aging Cerebellum.Cerebellum (London, England) · 2019Article
- Impaired Effective Connectivity During a Cerebellar-Mediated Sensorimotor Synchronization Task in Schizophrenia.Schizophrenia bulletin · 2019Article
- Reduction in gray matter of cerebellum in schizophrenia and its influence on static and dynamic connectivity.Human brain mapping · 2019Article
- Transgenic mice overexpressing miR-137 in the brain show schizophrenia-associated behavioral deficits and transcriptome profiles.PloS one · 2019Article
- Tremor after long term lithium treatment; is it cortical myoclonus?Cerebellum & ataxias · 2019Article
- Neural Correlates of Interval Timing Deficits in Schizophrenia.Frontiers in human neuroscience · 2019Review
- Aberrant timing and oddball detection in Schizophrenia: findings from a signed differential mapping meta-analysis.Heliyon · 2018Article
- Positive symptoms and time perception in schizophrenia: A meta-analysis.Schizophrenia research. Cognition · 2018Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Abnormalities in both time processing and dopamine (DA) neurotransmission have been observed in schizophrenia. Time processing seems to be linked to DA neurotransmission. The cognitive dysmetria hypothesis postulates that psychosis might be a manifestation of the loss of coordination of mental processes due to impaired timing. The objective of the present study was to analyze timing abilities and their corresponding functional neuroanatomy in schizophrenia. We performed a functional magnetic resonance imaging (fMRI) study using a predictive motor timing paradigm in 28 schizophrenia patients and 27 matched healthy controls (HC). The schizophrenia patients showed accelerated time processing compared to HC; the amount of the acceleration positively correlated with the degree of positive psychotic symptoms and negatively correlated with antipsychotic dose. This dysfunctional predictive timing was associated with BOLD signal activity alterations in several brain networks, especially those previously described as timing networks (basal ganglia, cerebellum, SMA, and insula) and reward networks (hippocampus, amygdala, and NAcc). BOLD signal activity in the cerebellar vermis was negatively associated with accelerated time processing. Several lines of evidence suggest a direct link between DA transmission and the cerebellar vermis that could explain their relevance for the neurobiology of schizophrenia.
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