ReviewExperimental biology and medicine (Maywood, N.J.)2016
Platelet-mimetic strategies for modulating the wound environment and inflammatory responses.
Review in Experimental biology and medicine (Maywood, N.J.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Ultrasoft platelet-like particles stop bleeding in rodent and porcine models of trauma.Science translational medicine · 2024Article
- Applications of injectable hemostatic materials in wound healing: principles, strategies, performance requirements, and future perspectives.Theranostics · 2023Review
- Advancement and Applications of Platelet-inspired Nanoparticles: A Paradigm for Cancer Targeting.Current pharmaceutical biotechnology · 2023Review
- Biomaterials for Hemostasis.Annual review of biomedical engineering · 2022Review
- Synthetic hydrogels as blood clot mimicking wound healing materials.Progress in biomedical engineering (Bristol, England) · 2021Article
- Platelet heterogeneity enhances blood clot volumetric contraction: An example of asynchrono-mechanical amplification.Biomaterials · 2021Article
- Biological Cells as Therapeutic Delivery Vehicles.Trends in pharmacological sciences · 2021Review
- Fibrin-Based Biomaterial Systems to Enhance Anterior Cruciate Ligament Healing.Medical devices & sensors · 2021Article
- Platelet-like particles improve fibrin network properties in a hemophilic model of provisional matrix structural defects.Journal of colloid and interface science · 2020Article
- Development of novel microenvironments for promoting enhanced wound healing.Current tissue microenvironment reports · 2020Article
- Nanosilver composite pNIPAm microgels for the development of antimicrobial platelet-like particles.Journal of biomedical materials research. Part B, Applied biomaterials · 2020Article
- Comparison of Neonatal and Adult Fibrin Clot Properties between Porcine and Human Plasma.Anesthesiology · 2020Article
- Development of biomimetic antimicrobial platelet-like particles comprised of microgel nanogold composites.Regenerative engineering and translational medicine · 2020Article
- Harnessing platelets as functional vectors for contrast enhanced ultrasound imaging and fluorescence imaging.RSC advances · 2019Article
- Engineered microparticles and nanoparticles for fibrinolysis.Journal of thrombosis and haemostasis : JTH · 2019Review
- The effect of platelet storage temperature on haemostatic, immune, and endothelial function: potential for personalised medicine.Blood transfusion = Trasfusione del sangue · 2019Review
- Platelet-like particles dynamically stiffen fibrin matrices and improve wound healing outcomes.Biomaterials science · 2019Article
- Biomimetic microgels with controllable deformability improve healing outcomes.Advanced biosystems · 2018Article
- Enhancing clot properties through fibrin-specific self-cross-linked PEG side-chain microgels.Colloids and surfaces. B, Biointerfaces · 2018Article
- Peptide Mimetic Drugs for Modulating Thrombosis and Hemostasis.Drug development research · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Platelets closely interface with the immune system to fight pathogens, target wound sites, and regulate tissue repair. Natural platelet levels within the body can be depleted for a variety of reasons, including excessive bleeding following traumatic injury, or diseases such as cancer and bacterial or viral infections. Platelet transfusions are commonly used to improve platelet count and hemostatic function in these cases, but transfusions can be complicated by the contamination risks and short storage life of donated platelets. Lyophilized platelets that can be freeze-dried and stored for longer periods of time and synthetic platelet-mimetic technologies that can enhance or replace the functions of natural platelets, while minimizing adverse immune responses have been explored as alternatives to transfusion. Synthetic platelets typically comprise nanoparticles surface-decorated with peptides or ligands to recreate specific biological characteristics of platelets, including targeting of wound and disease sites and facilitating platelet aggregation. Recent efforts in synthetic platelet design have additionally focused on matching platelet shape and mechanics to recreate the marginalization and clot contraction capabilities of natural platelets. The ability to specifically tune the properties of synthetic platelet-mimetic materials has shown utility in a variety of applications including hemostasis, drug delivery, and targeted delivery of cancer therapeutics.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.