Evidence map›Paper›PMID 27190253›Full record

ReviewExperimental biology and medicine (Maywood, N.J.)2016

Emerging nanotechnologies for cancer immunotherapy.

Sourabh Shukla, Nicole F Steinmetz

Open access · greenAbstract readReview
In one paragraph

Review in Experimental biology and medicine (Maywood, N.J.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Review
  3. Bringing p53 Back: A Prion-Powered Attack on Retinoblastoma.International journal of biological sciences · 2025
    Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
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  10. Review
  11. Article
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  13. Review
  14. Theranostics Applications of Nanoparticles in Cancer Immunotherapy.Medical sciences (Basel, Switzerland) · 2018
    Review
  15. Review
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sourabh ShuklaDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA sourabh.shukla@case.edu nicole.steinmetz@case.edu.
Nicole F SteinmetzDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA Department of Radiology, Case Western Reserve University, Cleveland, OH 44106, USA Department of Materials Science and Engineering, Case Western Reserve University, Cleveland, OH 44106, USA Department of Macromolecular Science and Engineering, Case Western Reserve University, Cleveland, OH 44106.
Case Western Reserve University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Founded on the growing insight into the complex cancer-immune system interactions, adjuvant immunotherapies are rapidly emerging and being adapted for the treatment of various human malignancies. Immune checkpoint inhibitors, for example, have already shown clinical success. Nevertheless, many approaches are not optimized, require frequent administration, are associated with systemic toxicities and only show modest efficacy as monotherapies. Nanotechnology can potentially enhance the efficacy of such immunotherapies by improving the delivery, retention and release of immunostimulatory agents and biologicals in targeted cell populations and tissues. This review presents the current status and emerging trends in such nanotechnology-based cancer immunotherapies including the role of nanoparticles as carriers of immunomodulators, nanoparticles-based cancer vaccines, and depots for sustained immunostimulation. Also highlighted are key translational challenges and opportunities in this rapidly growing field.

Indexed as

AnimalsChemotherapy, AdjuvantHumansImmunotherapyNanomedicineNeoplasmsCancer immunotherapyimmunomodulationnanotechnologyvaccines

Identifiers

PMID27190253
PMCPMC4950359
OpenAlexW2399227008

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.