ArticleDiabetes & vascular disease research2016
Risk stratification for 25-year cardiovascular disease incidence in type 1 diabetes: Tree-structured survival analysis of the Pittsburgh Epidemiology of Diabetes Complications study.
Article in Diabetes & vascular disease research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Reporting Quality of Machine Learning Studies on Pediatric Diabetes Mellitus: Systematic Review.Journal of medical Internet research · 2024Pooled it
- Remnant Cholesterol and Cardiovascular Risk in Adults With Type 1 Diabetes: A Nested Case-Control Study.Endocrinology, diabetes & metabolism · 2025Article
- Hyperlipidemia and Cardiovascular Disease in People with Type 1 Diabetes: Review of Current Guidelines and Evidence.Current cardiology reports · 2023Review
- Cardiovascular Disease in Adults with Type 1 Diabetes: Looking Beyond Glycemic Control.Current cardiology reports · 2022Review
- Arterial stiffness in patients with type 1 diabetes and its comparison to cardiovascular risk evaluation tools.Cardiovascular diabetology · 2022Article
- Risk factors differ by first manifestation of cardiovascular disease in type 1 diabetes.Diabetes research and clinical practice · 2020Article
- Article
- Artificial Intelligence Methodologies and Their Application to Diabetes.Journal of diabetes science and technology · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundThe formal identification of subgroups with varying levels of risk is uncommon in observational studies of cardiovascular disease, although such insight might be useful for clinical management.
methodsTree-structured survival analysis was utilized to determine whether there are meaningful subgroups at varying levels of cardiovascular disease risk in the Pittsburgh Epidemiology of Diabetes Complications study, a prospective cohort study of childhood-onset (<17 years old) type 1 diabetes.
resultsOf the 561 participants free of cardiovascular disease (coronary artery disease, stroke or lower extremity arterial disease) at baseline, 263 (46.9%) had an incident cardiovascular disease event over the 25-year follow-up. Tree-structured survival analysis revealed a range of risk groups, from 24% to 85%, which demonstrate that those with short diabetes duration and elevated non-high-density lipoprotein cholesterol have similar cardiovascular disease risk to those with long diabetes duration and that renal disease is a better discriminator of risk in men than in women.
conclusionOur findings suggest that subgroups with major cardiovascular disease risk differences exist in this type 1 diabetes cohort. Using tree-structured survival analysis may help to identify these groups and the interrelationships between their associated risk factors. This approach may improve our understanding of various clinical pathways to cardiovascular disease and help target intervention strategies.
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