Observational studyBrain : a journal of neurology2016
Corticolimbic anatomical characteristics predetermine risk for chronic pain.
Observational study in Brain : a journal of neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 213 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mind-body Treatments for Chronic Back Pain
Cognitive Flexibility Training in Persistent Pain
Cognitive Flexibility Training for Persistent Pain: Neuroimaging Pilot (COFLEX-i)
Who cites it
213 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Genome-wide association studies with experimental validation identify a protective role for B lymphocytes against chronic post-surgical pain.British journal of anaesthesia · 2024Pooled it
- A Systematic Review of MRI Studies and the "Emotional paiN and social Disconnect (END)" Brain Model of Suicidal Behavior in Youth.Behavioural neurology · 2023Pooled it
- Neural correlates of co-occurring pain and depression: an activation-likelihood estimation (ALE) meta-analysis and systematic review.Translational psychiatry · 2022Pooled it
- Dysregulated anterior insula reactivity as robust functional biomarker for chronic pain-Meta-analytic evidence from neuroimaging studies.Human brain mapping · 2022Pooled it
- Meta-analysis of neural systems underlying placebo analgesia from individual participant fMRI data.Nature communications · 2021Pooled it
- Effects of Chronic Pain Treatment on Altered Functional and Metabolic Activities in the Brain: A Systematic Review and Meta-Analysis of Functional Neuroimaging Studies.Frontiers in neuroscience · 2021Pooled it
- Is transcranial direct current stimulation (tDCS) effective for chronic low back pain? A systematic review and meta-analysis.Journal of neural transmission (Vienna, Austria : 1996) · 2020Pooled it
- Reconsolidation Blockade with Propranolol as a Novel Treatment for Chronic Low-Back Pain: A Double-Blind Randomized Placebo-Controlled Feasibility Study.Journal of pain research · 2026Trial
- Effects of Combined and Alone Transcranial Motor Cortex Stimulation and Mirror Therapy in Phantom Limb Pain: A Randomized Factorial Trial.Neurorehabilitation and neural repair · 2021Trial
- Evidence for decreased Neurologic Pain Signature activation following thoracic spinal manipulation in healthy volunteers and participants with neck pain.NeuroImage. Clinical · 2019Trial
- White matter tract microstructure of the mPFC-amygdala predicts interindividual differences in placebo response related to treatment in migraine patients.Human brain mapping · 2019Trial
- MEG-BMI to Control Phantom Limb Pain.Neurologia medico-chirurgica · 2018Trial
- Trial
- AMPA receptor, neuroimaging, and chronic pain.Journal of anesthesia · 2026Review
- Task-evoked network connectivity and pain regulation success in chronic low back pain.Neuroimage. Reports · 2026Article
- Brain dysconnectivity patterns associated with chronic back pain development.Brain informatics · 2026Article
- Review
- Article
- Influence of ginger root extract supplementation on the microbiota-gut-brain axis in individuals with sciatica: Study protocol for a double-blind, placebo-controlled randomized trial.Clinical nutrition ESPEN · 2026Article
- Vascular integrity and immune infiltration in SCI pain: Can exercise tip the balance?Experimental neurology · 2026Article
153 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
SEE TRACEY DOI101093/BRAIN/AWW147 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Mechanisms of chronic pain remain poorly understood. We tracked brain properties in subacute back pain patients longitudinally for 3 years as they either recovered from or transitioned to chronic pain. Whole-brain comparisons indicated corticolimbic, but not pain-related circuitry, white matter connections predisposed patients to chronic pain. Intra-corticolimbic white matter connectivity analysis identified three segregated communities: dorsal medial prefrontal cortex-amygdala-accumbens, ventral medial prefrontal cortex-amygdala, and orbitofrontal cortex-amygdala-hippocampus. Higher incidence of white matter and functional connections within the dorsal medial prefrontal cortex-amygdala-accumbens circuit, as well as smaller amygdala volume, represented independent risk factors, together accounting for 60% of the variance for pain persistence. Opioid gene polymorphisms and negative mood contributed indirectly through corticolimbic anatomical factors, to risk for chronic pain. Our results imply that persistence of chronic pain is predetermined by corticolimbic neuroanatomical factors.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.