ArticleGenome biology and evolution2016
Antibiotic Resistance, Core-Genome and Protein Expression in IncHI1 Plasmids in Salmonella Typhimurium.
Article in Genome biology and evolution, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- PlasAnn: a curated plasmid-specific database and annotation pipeline for standardized gene and function analysis.Nucleic acids research · 2026Article
- Virulence plasmids in edema disease: Insights from whole-genome analysis of porcine O139:H1 Shiga toxin-producingFrontiers in cellular and infection microbiology · 2025Article
- Characterization of anPathogens (Basel, Switzerland) · 2023Article
- IncHI1 plasmids mediated theFrontiers in microbiology · 2023Article
- Comparative analysis reveals the modular functional structure of conjugative megaplasmid pTTS12 ofFrontiers in microbiology · 2022Article
- Bacteria Broadly-Resistant to Last Resort Antibiotics Detected in Commercial Chicken Farms.Microorganisms · 2021Article
- Genomic Characterization of Multidrug-ResistantFrontiers in veterinary science · 2021Article
- Food Workers as a Reservoir of Extended-Spectrum-Cephalosporin-ResistantApplied and environmental microbiology · 2020Article
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- Implications of indoor microbial ecology and evolution on antibiotic resistance.Journal of exposure science & environmental epidemiology · 2020Review
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- Plasmid profiling and incompatibility grouping of multidrug resistant Salmonella enterica serovar Typhi isolates in Nairobi, Kenya.BMC research notes · 2019Article
- Mobile Genetic Elements Associated with Antimicrobial Resistance.Clinical microbiology reviews · 2018Review
- Complexity of Antibiotic Resistance in Commensal Escherichia coli Derived from Pigs from an Intensive-Production Farm.Microbes and environments · 2018Article
- Multidrug-resistant Citrobacter freundii ST139 co-producing NDM-1 and CMY-152 from China.Scientific reports · 2018Article
- Characterization of a novel multidrug resistance plasmid pSGB23 isolated fromGut pathogens · 2018Article
- Complete Nucleotide Sequences of Two VIM-1-Encoding Plasmids from Klebsiella pneumoniae and Leclercia adecarboxylata Isolates of Czech Origin.Antimicrobial agents and chemotherapy · 2017Article
- Exploring the Genome and Phenotype of Multi-Drug ResistantFrontiers in microbiology · 2017Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Conjugative plasmids from the IncHI1 incompatibility group play an important role in transferring antibiotic resistance in Salmonella Typhimurium. However, knowledge of their genome structure or gene expression is limited. In this study, we determined the complete nucleotide sequences of four IncHI1 plasmids transferring resistance to antibiotics by two different next generation sequencing protocols and protein expression by mass spectrometry. Sequence data including additional 11 IncHI1 plasmids from GenBank were used for the definition of the IncHI1 plasmid core-genome and pan-genome. The core-genome consisted of approximately 123 kbp and 122 genes while the total pan-genome represented approximately 600 kbp. When the core-genome sequences were used for multiple alignments, the 15 tested IncHI1 plasmids were separated into two main lineages. GC content in core-genome genes was around 46% and 50% in accessory genome genes. A multidrug resistance region present in all 4 sequenced plasmids extended over 20 kbp and, except for tet(B), the genes responsible for antibiotic resistance were those with the highest GC content. IncHI1 plasmids therefore represent replicons that evolved in low GC content bacteria. From their original host, they spread to Salmonella and during this spread these plasmids acquired multiple accessory genes including those coding for antibiotic resistance. Antibiotic-resistance genes belonged to genes with the highest level of expression and were constitutively expressed even in the absence of antibiotics. This is the likely mechanism that facilitates host cell survival when antibiotics suddenly emerge in the environment.
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