ArticleGenome biology and evolution2016
Detection of Allelic Frequency Differences between the Sexes in Humans: A Signature of Sexually Antagonistic Selection.
Article in Genome biology and evolution, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Drivers of systemic male-female allele frequency divergence in humans.bioRxiv : the preprint server for biology · 2026Article
- Pervasive sex-dependent effects in the genetic architecture of starvation resistance inScience advances · 2025Article
- Sexual Antagonism and Sex Determination in Three Syngnathid Species Alongside a Male Pregnancy Gradient.Genome biology and evolution · 2025Article
- The maintenance of genetic polymorphism underlying sexually antagonistic traits.Evolution letters · 2025Article
- Evolutionary divergence between homologous X-Y chromosome genes shapes sex-biased biology.Nature ecology & evolution · 2025Article
- The battle of the sexes in humans is highly polygenic.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- On the resolution of sexual conflict over shared traits.Proceedings. Biological sciences · 2024Review
- Unveiling recent and ongoing adaptive selection in human populations.PLoS biology · 2024Article
- The roles of sexual selection and sexual conflict in shaping patterns of genome and transcriptome variation.Nature ecology & evolution · 2023Review
- Evolutionary dynamics of pseudoautosomal region 1 in humans and great apes.Genome biology · 2022Article
- Article
- Genome-wide interaction analysis identified low-frequency variants with sex disparity in lung cancer risk.Human molecular genetics · 2022Article
- Sex-specific natural selection on SNPs inEvolution letters · 2022Article
- Detection of sexually antagonistic transmission distortions in trio datasets.Evolution letters · 2022Article
- An unbiased test reveals no enrichment of sexually antagonistic polymorphisms on the human X chromosome.Proceedings. Biological sciences · 2022Article
- Experimental evolution reveals sex-specific dominance for surviving bacterial infection in laboratory populations ofEvolution letters · 2021Article
- Review
- Identification of genomic regions that exhibit sexual dimorphism for size and muscularity in cattle.Journal of animal science · 2021Article
- Evolutionary dynamics of the human pseudoautosomal regions.PLoS genetics · 2021Article
- Evaluating human autosomal loci for sexually antagonistic viability selection in two large biobanks.Genetics · 2021Article
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Authors and funding
5 authors.
Funding
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Abstract
Sexually antagonistic (SA) selection, a form of selection that can occur when both sexes have different fitness optima for a trait, is a major force shaping the evolution of organisms. A seminal model developed by Rice (Rice WR. 1984. Sex chromosomes and the evolution of sexual dimorphism. Evolution 38:735-742.) predicts that the X chromosome should be a hotspot for the accumulation of loci under SA selection as compared with the autosomes. Here, we propose a methodological framework designed to detect a specific signature of SA selection on viability, differences in allelic frequencies between the sexes. Applying this method on genome-wide single nucleotide polymorphism (SNP) data in human populations where no sex-specific population stratification could be detected, we show that there are overall significantly more SNPs exhibiting differences in allelic frequencies between the sexes on the X chromosome as compared with autosomes, supporting the predictions of Rice's model. This pattern is consistent across populations and is robust to correction for potential biases such as differences in linkage disequilibrium, sample size, and genotyping errors between chromosomes. Although SA selection is not the only factor resulting in allelic frequency differences between the sexes, we further show that at least part of the identified X-linked loci is caused by such a sex-specific processes.
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