ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2017
Advancing age and ischemia elevate the electric threshold to elicit spreading depolarization in the cerebral cortex of young adult rats.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Spreading depolarization causes reperfusion failure after cerebral ischemia.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Relationship between temporal dynamics of intrinsic brain activity and motor function remodeling in patients with acute BGIS.Frontiers in neuroscience · 2023Article
- The Critical Role of Spreading Depolarizations in Early Brain Injury: Consensus and Contention.Neurocritical care · 2022Review
- Malignant astrocyte swelling and impaired glutamate clearance drive the expansion of injurious spreading depolarization foci.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Comparative analysis of spreading depolarizations in brain slices exposed to osmotic or metabolic stress.BMC neuroscience · 2021Article
- Microglia alter the threshold of spreading depolarization and related potassium uptake in the mouse brain.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- NMDA attenuates the neurovascular response to hypercapnia in the neonatal cerebral cortex.Scientific reports · 2019Article
- Spreading depression as a preclinical model of migraine.The journal of headache and pain · 2019Review
- Neurovascular mechanisms of migraine and cluster headache.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Review
- Brain Aging and Electrophysiological Signaling: Revisiting the Spreading Depression Model.Frontiers in aging neuroscience · 2019Review
- Spectral and Multifractal Signature of Cortical Spreading Depolarisation in Aged Rats.Frontiers in physiology · 2018Article
- Age-related impairment of metabovascular coupling during cortical spreading depolarizations.American journal of physiology. Heart and circulatory physiology · 2017Article
- Spreading depolarization remarkably exacerbates ischemia-induced tissue acidosis in the young and aged rat brain.Scientific reports · 2017Article
- Functional vascular contributions to cognitive impairment and dementia: mechanisms and consequences of cerebral autoregulatory dysfunction, endothelial impairment, and neurovascular uncoupling in aging.American journal of physiology. Heart and circulatory physiology · 2017Review
- Contribution of prostanoid signaling to the evolution of spreading depolarization and the associated cerebral blood flow response.Scientific reports · 2016Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spreading depolarizations of long cumulative duration have been implicated in lesion development and progression in patients with stroke and traumatic brain injury. Spreading depolarizations evolve less likely in the aged brain, but it remains to be determined at what age the susceptibility to spreading depolarizations starts to decline, especially in ischemia. Spreading depolarizations were triggered by epidural electric stimulation prior and after ischemia induction in the cortex of 7-30 weeks old anesthetized rats ( n = 38). Cerebral ischemia was achieved by occlusion of both common carotid arteries. Spreading depolarization occurrence was confirmed by the acquisition of DC potential and electrocorticogram. Cerebral blood flow variations were recorded by laser-Doppler flowmetry. Dendritic spine density in the cortex was determined in Golgi-COX stained sections. Spreading depolarization initiation required increasingly greater electric charge with older age, a potential outcome of consolidation of cortical connections, indicated by altered dendritic spine distribution. The threshold of spreading depolarization elicitation increased with ischemia in all age groups, which may be caused by tissue acidosis and increased K
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