ArticleJournal of neuroscience methods2016
Individually customisable non-invasive head immobilisation system for non-human primates with an option for voluntary engagement.
Article in Journal of neuroscience methods, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 39 citations in OpenAlex.
- Home-Cage Training for Non-Human Primates: An Opportunity to Reduce Stress and Study Natural Behavior in Neurophysiology Experiments.Animals : an open access journal from MDPI · 2025Review
- Evolutionarily conserved fMRI network dynamics in the mouse, macaque, and human brain.Nature communications · 2024Article
- Brain intrinsic connection patterns underlying tool processing in human adults are present in neonates and not in macaques.NeuroImage · 2022Article
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- Optimization of a quadrature birdcage coil for functional imaging of squirrel monkey brain at 9.4T.Magnetic resonance imaging · 2021Article
- MRI monitoring of macaque monkeys in neuroscience: Case studies, resource and normative data comparisons.NeuroImage · 2021Article
- International primate neuroscience research regulation, public engagement and transparency opportunities.NeuroImage · 2021Review
- Cross-species functional alignment reveals evolutionary hierarchy within the connectome.NeuroImage · 2020Article
- A review of 3D printed patient specific immobilisation devices in radiotherapy.Physics and imaging in radiation oncology · 2020Article
- Interindividual Variability of Functional Connectivity in Awake and Anesthetized Rhesus Macaque Monkeys.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Article
- Gradients of connectivity distance in the cerebral cortex of the macaque monkey.Brain structure & function · 2019Article
- Reward cues readily direct monkeys' auditory performance resulting in broad auditory cortex modulation and interaction with sites along cholinergic and dopaminergic pathways.Scientific reports · 2019Article
- Ethical and Scientific Pitfalls Concerning Laboratory Research with Non-Human Primates, and Possible Solutions.Animals : an open access journal from MDPI · 2018Article
- Improved methods for MRI-compatible implants in nonhuman primates.Journal of neuroscience methods · 2018Article
- Real-time visuomotor behavior and electrophysiology recording setup for use with humans and monkeys.Journal of neurophysiology · 2018Article
- Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundHead immobilisation is often necessary for neuroscientific procedures. A number of Non-invasive Head Immobilisation Systems (NHIS) for monkeys are available, but the need remains for a feasible integrated system combining a broad range of essential features. NEW
methodWe developed an individualised macaque NHIS addressing several animal welfare and scientific needs. The system comprises a customised-to-fit facemask that can be used separately or combined with a back piece to form a full-head helmet. The system permits presentation of visual and auditory stimuli during immobilisation and provides mouth access for reward.
resultsThe facemask was incorporated into an automated voluntary training system, allowing the animals to engage with it for increasing periods leading to full head immobilisation. We evaluated the system during performance on several auditory or visual behavioural tasks with testing sessions lasting 1.5-2h, used thermal imaging to monitor for and prevent pressure points, and measured head movement using MRI. COMPARISON WITH EXISTING
methodsA comprehensive evaluation of the system is provided in relation to several scientific and animal welfare requirements. Behavioural results were often comparable to those obtained with surgical implants. Cost-benefit analyses were conducted comparing the system with surgical options, highlighting the benefits of implementing the non-invasive option.
conclusionsThe system has a number of potential applications and could be an important tool in neuroscientific research, when direct access to the brain for neuronal recordings is not required, offering the opportunity to conduct non-invasive experiments while improving animal welfare and reducing reliance on surgically implanted head posts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.