ArticleScientific reports2016
A Novel Strategy for Live Detection of Viral Infection in Drosophila melanogaster.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Detection of Nora virus in infectedFly · 2026Article
- Persistent viral infection in the Drosophila fat body is associated with immune activation at the single cell level.BMC genomics · 2026Article
- Asymmetric biparental and inefficient horizontal transmission of paralysis-causing sigmavirus in Queensland fruit fly.Heredity · 2026Article
- The Gut Microbiota ofMicroorganisms · 2025Review
- Nora virus proliferates in dividing intestinal stem cells and sensitizes flies to intestinal infection and oxidative stress.bioRxiv : the preprint server for biology · 2025Article
- Naturally occurring viruses ofProceedings. Biological sciences · 2024Article
- The potential use ofTurkish journal of biology = Turk biyoloji dergisi · 2021Article
- Tracking Mechanisms of Viral Dissemination In Vivo.Trends in cell biology · 2021Review
- Structure of Nora virus at 2.7 Å resolution and implications for receptor binding, capsid stability and taxonomy.Scientific reports · 2020Article
- Application of the Mesolens for subcellular resolution imaging of intact larval and whole adult Drosophila.Journal of microscopy · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have created a transgenic reporter for virus infection, and used it to study Nora virus infection in Drosophila melanogaster. The transgenic construct, Munin, expresses the yeast transcription factor Gal4, tethered to a transmembrane anchor via a linker that can be cleaved by a viral protease. In infected cells, liberated Gal4 will then transcribe any gene that is linked to a promoter with a UAS motif, the target for Gal4 transcription. For instance, infected cells will glow red in the offspring of a cross between the Munin stock and flies with a UAS-RFP(nls) transgene (expressing a red fluorescent protein). In such flies we show that after natural infection, via the faecal-oral route, 5-15% of the midgut cells are infected, but there is little if any infection elsewhere. By contrast, we can detect infection in many other tissues after injection of virus into the body cavity. The same principle could be applied for other viruses and it could also be used to express or suppress any gene of interest in infected cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.