ReviewClinical and molecular hepatology2016
Benign hepatocellular nodules of healthy liver: focal nodular hyperplasia and hepatocellular adenoma.
Review in Clinical and molecular hepatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Burden of Liver Disease Among Individuals With Turner Syndrome and Klinefelter Syndrome: A Comprehensive Perspective.Chronic diseases and translational medicine · 2026Article
- Case Report: Focal nodular hyperplasia of the liver in an adolescent-a case report and literature review.Frontiers in pediatrics · 2026Article
- Focal Hyperechoic Hepatic Lesions in Northern Region of Saudi Arabia: Prevalence, Radiologic Features, and Clinical Relevance.Journal of clinical medicine · 2025Article
- Diagnosis and Management of Benign Liver Tumors.The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2025Review
- Focal nodular hyperplasia combined with hepatocellular carcinoma with bone metastasis: a case report and literature review.Frontiers in oncology · 2025Article
- Pedunculated Focal Nodular Hyperplasia: When in Doubt, Should We Cut It Out?Journal of clinical medicine · 2023Review
- Desmoplastic small round cell tumor of the liver: diagnosing a rare case on liver biopsy.Diagnostic pathology · 2023Article
- Hepatocellular Neoplasm of Uncertain Potential of Malignancy or Well-Differentiated Hepatocellular Carcinoma Arising within Hepatocellular Adenoma.Case reports in surgery · 2023Article
- Liver Abnormalities in Turner Syndrome: The Importance of Estrogen Replacement.Journal of the Endocrine Society · 2022Review
- Magnetic Resonance Imaging Findings of an Intrahepatic Bile Duct Adenoma: A Case Report.Cureus · 2022Article
- Comparison of the Value of Color Doppler Ultrasound and Multislice Spiral CT in the Differential Diagnosis of Benign and Malignant Nodules in the Liver.Contrast media & molecular imaging · 2022Article
- Senescence markers in focal nodular hyperplasia of the liver: pathogenic considerations on the basis of immunohistochemical results.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2022Article
- Genomic analysis of focal nodular hyperplasia with associated hepatocellular carcinoma unveils its malignant potential: a case report.Communications medicine · 2022Article
- Diagnosis and surgical treatment of a rare hepatic angiomyolipoma with internal hemorrhage.Annals of hepato-biliary-pancreatic surgery · 2021Article
- Alpha-fetoprotein and focal nodular hyperplasia: An unconventional couple.JGH open : an open access journal of gastroenterology and hepatology · 2021Article
- Scoping review of clinical practice guidelines on the management of benign liver tumours.BMJ open gastroenterology · 2021Article
- Hepatocellular adenomas: recent updates.Journal of pathology and translational medicine · 2021Review
- Appearance of Focal Nodular Hyperplasia after Chemotherapy in Two Patients during Follow-Up of Colon Carcinoma.Case reports in surgery · 2021Article
- Panel of potential lncRNA biomarkers can distinguish various types of liver malignant and benign tumors.Journal of cancer research and clinical oncology · 2021Article
- Patterns of enhancement in the hepatobiliary phase of gadoxetic acid-enhanced MRI.The British journal of radiology · 2020Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Owing to the progress of imaging techniques, benign hepatocellular nodules are increasingly discovered in the clinical practice. This group of lesions mostly arises in the context of a putatively normal healthy liver and includes either pseudotumoral and tumoral nodules. Focal nodular hyperplasia and hepatocellular adenoma are prototypical examples of these two categories of nodules. In this review we aim to report the main pathological criteria of differential diagnosis between focal nodular hyperplasia and hepatocellular adenoma, which mainly rests upon morphological and phenotypical features. We also emphasize that for a correct diagnosis the clinical context such as sex, age, assumption of oral contraceptives, associated metabolic or vascular disturbances is of paramount importance. While focal nodular hyperplasia is a single entity epidemiologically more frequent than adenoma, the latter is representative of a more heterogeneous group which has been recently and extensively characterized from a clinical, morphological, phenotypical and molecular profile. The use of the liver biopsy in addition to imaging and the clinical context are important diagnostic tools of these lesions. In this review we will survey their systematic pathobiology and propose a diagnostic algorithm helpful to increase the diagnostic accuracy of not dedicated liver pathologists. The differential diagnosis between so-called typical and atypical adenoma and well differentiated hepatocellular carcinoma will also be discussed.
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