Trial reportJournal of pediatric psychology2016
Investigating the Role of Hypothalamic Tumor Involvement in Sleep and Cognitive Outcomes Among Children Treated for Craniopharyngioma.
Trial report in Journal of pediatric psychology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Pooled it
- Sleep Disturbances in Pediatric Craniopharyngioma: A Systematic Review.Frontiers in neurology · 2022Pooled it
- Sleep circuit modulation: from animal models to human translation.Brain : a journal of neurology · 2026Review
- A longitudinal assessment of sleep architecture in children and adolescents with craniopharyngioma.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Endocrine and metabolic consequences of childhood-onset craniopharyngioma during the transition age: A literature review by the TALENT study group.Reviews in endocrine & metabolic disorders · 2025Review
- Sleep Disorders, Dysregulation of Circadian Rhythms, and Fatigue After Craniopharyngioma-A Narrative Review.Biomedicines · 2025Review
- Review
- Performance and symptom validity indicators among children undergoing cognitive surveillance following treatment for craniopharyngioma.Neuro-oncology practice · 2024Article
- Article
- Sleep Disturbance and Its Association With Sluggish Cognitive Tempo and Attention in Pediatric Brain Tumor Survivors.Frontiers in neuroscience · 2022Article
- Prevalence of Sleep Disturbances in Pediatric Cancer Patients and Their Diagnosis and Management.Children (Basel, Switzerland) · 2021Review
- Impact of sleep, neuroendocrine, and executive function on health-related quality of life in young people with craniopharyngioma.Developmental medicine and child neurology · 2021Article
- Sleep Disorders in Patients With Craniopharyngioma: A Physiopathological and Practical Update.Frontiers in neurology · 2021Review
- Predictors of narcolepsy and hypersomnia due to medical disorder in pediatric craniopharyngioma.Journal of neuro-oncology · 2020Article
- Article
- Prevalence, risk factors, and response to treatment for hypersomnia of central origin in survivors of childhood brain tumors.Journal of neuro-oncology · 2018Article
- Sleep Problems as Consequence, Contributor, and Comorbidity: Introduction to the Special Issue on Sleep, Published in Coordination With Special Issues in Clinical Practice in Pediatric Psychology and Journal of Developmental and Behavioral Pediatrics.Journal of pediatric psychology · 2016Article
- Symptoms in Children Receiving Treatment for Cancer-Part I: Fatigue, Sleep Disturbance, and Nausea/Vomiting.Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology NursesReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveDespite excellent survival prognosis, children treated for craniopharyngioma experience significant morbidity. We examined the role of hypothalamic involvement (HI) in excessive daytime sleepiness (EDS) and attention regulation in children enrolled on a Phase II trial of limited surgery and proton therapy.
methodsParticipants completed a sleep evaluation (N = 62) and a continuous performance test (CPT) during functional magnetic resonance imaging (fMRI; n = 29) prior to proton therapy.
resultsEDS was identified in 76% of the patients and was significantly related to increased HI extent (p = .04). There was no relationship between CPT performance during fMRI and HI or EDS. Visual examination of group composite fMRI images revealed greater spatial extent of activation in frontal cortical regions in patients with EDS, consistent with a compensatory activation hypothesis.
conclusionRoutine screening for sleep problems during therapy is indicated for children with craniopharyngioma, to optimize the timing of interventions and reduce long-term morbidity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.