Evidence map›Paper›PMID 27189615›Full record

Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2016

Chamomile infusion cryotherapy to prevent oral mucositis induced by chemotherapy: a pilot study.

Paula Elaine Diniz Dos Reis, Marcia A Ciol, Nilce Santos de Melo, Paulo Tadeu de Souza Figueiredo, André Ferreira Leite, Natália de Melo Manzi

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 9 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 9 syntheses or guidelines pooled it, 68 citations in OpenAlex.

  1. Pooled it
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  3. Medicinal plants used for the treatment of mucositis induced by oncotherapy: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Pooled it
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  5. Eficacy of Cryotherapy in the Prevention of Oral Mucosistis in Adult Patients with Chemotherapy.International journal of environmental research and public health · 2021
    Pooled it
  6. Systematic review of oral cryotherapy for the management of oral mucositis in cancer patients and clinical practice guidelines.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Paula Elaine Diniz Dos ReisNursing Department, School of Health Sciences, University of Brasília, Darcy Ribeiro University Campus, Asa Norte, Brasilia, Federal District, 71100-070, Brazil. pauladiniz@unb.br.
Marcia A CiolDepartment of Rehabilitation Medicine, School of Medicine, University of Washington, Seattle, WA, USA.
Nilce Santos de MeloDentistry Department, School of Health Sciences, University of Brasília, Brasília, DF, Brazil.
Paulo Tadeu de Souza FigueiredoDentistry Department, School of Health Sciences, University of Brasília, Brasília, DF, Brazil.
André Ferreira LeiteDentistry Department, School of Health Sciences, University of Brasília, Brasília, DF, Brazil.
Natália de Melo ManziMedical Department, Senado Federal, Brasília, DF, Brazil.
Universidade de Brasília · BRFederal Senate · BRUniversity of Washington · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this study is to compare cryotherapy made only with water and cryotherapy made with chamomile infusion for prevention and reduction of intensity of oral mucositis in patients with cancer receiving 5-fluorouracil and leucovorin.

methodThis is a randomized pilot study with two groups: cryotherapy made only with water (control group, n = 18) and cryotherapy made with chamomile infusion (chamomile group, n = 20). Both groups were instructed to swish the ice around in their oral cavity for at least 30 min during chemotherapy. Assessment of oral mucosa occurred on days 8, 15, and 22 after the first day of chemotherapy.

resultsFifty percent of the patients in the control and 30 % in the chamomile group developed oral mucositis. Mouth pain score was higher in patients in the control group on all evaluations (p = 0.02 for day 8, p = 0.09 for day 15, and p = 0.14 for day 22). Patients in the chamomile group never developed mucositis with grade 2 or higher. Presence of ulceration was statistically significant on day 8 (16 % in the control vs. 0 % in the chamomile group, p = 0.10), but not in days 15 and 22, although 11 % still had ulcerations in the control group and none in the chamomile group.

conclusionThe occurrence of oral mucositis was lower in patients in the chamomile group than in the control group. When compared to the controls, the chamomile group presented less mouth pain and had no ulcerations. Cryotherapy was well tolerated by both groups, and no toxicity related to chamomile was identified.

Indexed as

ChamomileCryotherapyFemaleHumansMaleMiddle AgedNeoplasmsPilot ProjectsStomatitisCancerChemotherapyCryotherapyOral careOral mucositis

Identifiers

PMID27189615
OpenAlexW2394802534

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.