Evidence map›Paper›PMID 27189416›Full record

ReviewNature reviews. Disease primers2015

Colorectal cancer.

Ernst J Kuipers, William M Grady, David Lieberman, Thomas Seufferlein, Joseph J Sung, Petra G Boelens, Cornelis J H van de Velde, Toshiaki Watanabe

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Disease primers, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 945 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
945citing papers in PubMed, 5 pooled it
12.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

945 citing papers in PubMed, 5 syntheses or guidelines pooled it, 1,541 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Article
  11. Article
  12. ER-Localized DeadenylaseExploration (Beijing, China) · 2026
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. TGF-β Pathway-Based Polygenic Risk Score Modifies the Association between Red Meat Intake and Colorectal Cancer Risk: Application of a Novel Pathway-Based PRS Method.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026
    Article

885 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 5 countries.

Ernst J KuipersErasmus MC University Medical Center, s-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands.
William M GradyClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
David LiebermanDivision of Gastroenterology and Hepatology, Oregon Health and Science University, Portland, Oregon, USA.
Thomas SeufferleinDepartment of Internal Medicine I, University of Ulm, Ulm, Germany.
Joseph J SungDepartment of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong, China.
Petra G BoelensDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
Cornelis J H van de VeldeDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
Toshiaki WatanabeDepartment of Surgical Oncology and Vascular Surgery, University of Tokyo and the University of Tokyo Hospital, Tokyo, Japan.
Leiden University Medical Center · NLChinese University of Hong Kong · CNErasmus MC · NLFred Hutch Cancer Center · USOregon Health & Science University · USUniversität Ulm · DEUniversity of Tokyo Hospital · JP

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
(PQC1) Accelerated biological aging and colon polyp to cancer progressionR01CA194663 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI GRADY, WILLIAM MALLORY · 2015 to 2018
$1.6M
NCI NIH HHS P30 CA015704NCI NIH HHS R01 CA194663
6 · The paper itself

Abstract

Colorectal cancer had a low incidence several decades ago. However, it has become a predominant cancer and now accounts for approximately 10% of cancer-related mortality in western countries. The 'rise' of colorectal cancer in developed countries can be attributed to the increasingly ageing population, unfavourable modern dietary habits and an increase in risk factors, such as smoking, low physical exercise and obesity. New treatments for primary and metastatic colorectal cancer have emerged, providing additional options for patients; these treatments include laparoscopic surgery for primary disease, more-aggressive resection of metastatic disease (such as liver and pulmonary metastases), radiotherapy for rectal cancer, and neoadjuvant and palliative chemotherapies. However, these new treatment options have had limited impact on cure rates and long-term survival. For these reasons, and the recognition that colorectal cancer is long preceded by a polypoid precursor, screening programmes have gained momentum. This Primer provides an overview of the current state of the art of knowledge on the epidemiology and mechanisms of colorectal cancer, as well as on diagnosis and treatment.

Indexed as

Colorectal NeoplasmsAntineoplastic Combined Chemotherapy ProtocolsColectomyColonic PolypsHumansIncidenceLaparoscopyRadiotherapyRisk Factors

Identifiers

PMID27189416
PMCPMC4874655
OpenAlexW4211001330

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.