ArticleScientific reports2016
Polar flagella rotation in Vibrio parahaemolyticus confers resistance to bacteriophage infection.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Functional genomics of chitin degradation by Vibrio parahaemolyticus reveals finely integrated metabolic contributions to support environmental fitness.PLoS genetics · 2025Article
- The LuxO-OpaR quorum-sensing cascade differentially controls Vibriophage VP882 lysis-lysogeny decision making in liquid and on surfaces.PLoS genetics · 2024Article
- Role of Bacteriophages in the Evolution of Pathogenic Vibrios and Lessons for Phage Therapy.Advances in experimental medicine and biology · 2023Article
- A Tripartite Efflux System Affects Flagellum Stability inInternational journal of molecular sciences · 2022Article
- Mechanisms of interactions between bacteria and bacteriophage mediate by quorum sensing systems.Applied microbiology and biotechnology · 2022Review
- Article
- Marine Actinomycetes, New Sources of Biotechnological Products.Marine drugs · 2021Review
- Interdependent Polar Localization of FlhF and FlhG and Their Importance for Flagellum Formation ofFrontiers in microbiology · 2021Article
- Article
- Identification of a novel bacterial receptor that binds tail tubular proteins and mediates phage infection ofEmerging microbes & infections · 2020Article
- Distinct chemotactic behavior in the original Escherichia coli K-12 depending on forward-and-backward swimming, not on run-tumble movements.Scientific reports · 2020Article
- Phages as a Cohesive Prophylactic and Therapeutic Approach in Aquaculture Systems.Antibiotics (Basel, Switzerland) · 2020Review
- Phylogenetic Distribution, Ultrastructure, and Function of Bacterial Flagellar Sheaths.Biomolecules · 2020Review
- Isolation and Characterization of the Novel Phages vB_VpS_BA3 and vB_VpS_CA8 for LysingFrontiers in microbiology · 2020Article
- Phage Reduce Stability for Regaining Infectivity during Antagonistic Coevolution with Host Bacterium.Viruses · 2019Article
- Targeting mechanisms of tailed bacteriophages.Nature reviews. Microbiology · 2018Review
- Natural Transformation in Vibrio parahaemolyticus: a Rapid Method To Create Genetic Deletions.Journal of bacteriology · 2018Article
- Review
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Bacteriophage has been recognized as a novel approach to treat bacterial infectious diseases. However, phage resistance may reduce the efficacy of phage therapy. Here, we described a mechanism of bacterial resistance to phage infections. In Gram-negative enteric pathogen Vibrio parahaemolyticus, we found that polar flagella can reduce the phage infectivity. Deletion of polar flagella, but not the lateral flagella, can dramatically promote the adsorption of phage to the bacteria and enhances the phage infectivity to V. parahaemolyticus, indicating that polar flagella play an inhibitory role in the phage infection. Notably, it is the rotation, not the physical presence, of polar flagella that inhibits the phage infection of V. parahaemolyticus. Strikingly, phage dramatically reduces the virulence of V. parahaemolyticus only when polar flagella were absent both in vitro and in vivo. These results indicated that polar flagella rotation is a previously unidentified mechanism that confers bacteriophage resistance.
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