ArticleReproductive toxicology (Elmsford, N.Y.)2016
The human placental proteome is affected by maternal smoking.
Article in Reproductive toxicology (Elmsford, N.Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- Vitamin C supplementation improves placental function and alters placental gene expression in smokers.Scientific reports · 2024Trial
- Maternal mental health disorders associate with their child's asthma: A register-based study.Brain, behavior, & immunity - health · 2025Article
- Physically active pregnancies: Insights from the placenta.Physiological reports · 2024Review
- Evaluation of Lippia scaberrima Sond. and Aspalathus linearis (Burm.f.) R. Dahlgren extracts on human CYP enzymes and gold nanoparticle synthesis: implications for drug metabolism and cytotoxicity.BMC complementary medicine and therapies · 2024Article
- Predicting Human Fetal Drug Exposure Through Maternal-Fetal PBPK Modeling and In Vitro or Ex Vivo Studies.Journal of clinical pharmacology · 2022Review
- Prenatal particulate matter exposure and mitochondrial mutational load at the maternal-fetal interface: Effect modification by genetic ancestry.Mitochondrion · 2022Article
- Aflatoxin B1 targeted gene expression profiles in human placental primary trophoblast cells.Current research in toxicology · 2022Article
- Proteome profiling of human placenta reveals developmental stage-dependent alterations in protein signature.Clinical proteomics · 2021Article
- Cigarette Smoking and Estrogen-Related Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021Review
- Associations Between Maternal Lifetime Stress and Placental Mitochondrial DNA Mutations in an Urban Multiethnic Cohort.Biological psychiatry · 2021Article
- A toolkit for the application of placental-fetal molecular biomarkers in epidemiologic studies of the fetal origins of chronic disease.Current epidemiology reports · 2021Article
- Transcriptomics and Other Omics Approaches to Investigate Effects of Xenobiotics on the Placenta.Frontiers in cell and developmental biology · 2021Review
- Differences in cytochrome p450 enzyme expression and activity in fetal and adult tissues.Placenta · 2020Article
- Altered expression of 17‑β‑hydroxysteroid dehydrogenase type 2 and its prognostic significance in non‑small cell lung cancer.International journal of oncology · 2020Article
- In Vitro Human Metabolism and Inhibition Potency of Verbascoside for CYP Enzymes.Molecules (Basel, Switzerland) · 2019Article
- Nutrient transporter expression in both the placenta and fetal liver are affected by maternal smoking.Placenta · 2019Article
- Kuopio birth cohort - design of a Finnish joint research effort for identification of environmental and lifestyle risk factors for the wellbeing of the mother and the newborn child.BMC pregnancy and childbirth · 2018Article
- Integrating -Omics Approaches into Human Population-Based Studies of Prenatal and Early-Life Exposures.Current environmental health reports · 2018Review
- Biases Inherent in Studies of Coffee Consumption in Early Pregnancy and the Risks of Subsequent Events.Nutrients · 2018Review
- The human fetal adrenal produces cortisol but no detectable aldosterone throughout the second trimester.BMC medicine · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
Detrimental effects of maternal smoking on the term placental proteome and steroid-metabolizing activities, and maternal hormone levels, were studied by using seven non-smoker and seven smoker placentae. Smoking significantly affected 18% of protein spots. The functional networks affected were i) cell morphology, cellular assembly and organization, cellular compromise (15 hits) and ii) DNA replication, recombination, and repair, energy production, nucleic acid metabolism (6 hits). Smoking significantly up-regulated such proteins as, SERPINA1, EFHD1 and KRT8; and down-regulated SERPINB2, FGA and HBB. Although maternal plasma steroids were not significantly altered, the catalytic activity of CYP1A1 was increased whereas CYP19A1 activity was reduced by smoking. Furthermore, transcript expression of CYP1A1 and CYP4B1 were induced while HSD17B2, NFKB and TGFB1 were repressed by smoking. The observed smoking induced wide-spread changes on placental proteome and transcript levels may contribute to the lowered birth weights of the new-born child and placenta.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.