Evidence map›Paper›PMID 27189222›Full record

ArticleEndocrine pathology2017

TFE3-Expressing Perivascular Epithelioid Cell Neoplasm (PEComa) of the Sella Turcica.

Martin D Hyrcza, Daniel A Winer, Mary Shago, Karolyn Au, Gelareh Zadeh, Sylvia L Asa, Ozgur Mete

Abstract readCase Reports
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In one paragraph

Article in Endocrine pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Exploring perivascular epithelioid cell tumors (PEComas) in the CNS: insights from two case reports and a comprehensive literature review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025
    Review
  3. Article
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Martin D HyrczaDepartment of Pathology, University Health Network, Toronto, ON, Canada.
Daniel A WinerDepartment of Pathology, University Health Network, Toronto, ON, Canada.
Mary ShagoDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
Karolyn AuDepartment of Neurosurgery, University Health Network and University of Toronto, Toronto, Ontario, Canada.
Gelareh ZadehEndocrine Oncology Site Group, The Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
Sylvia L AsaDepartment of Pathology, University Health Network, Toronto, ON, Canada.
Ozgur MeteDepartment of Pathology, University Health Network, Toronto, ON, Canada. ozgur.mete2@uhn.ca.
University of Toronto · CAPrincess Margaret Cancer Centre · CAUniversity Health Network · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a primary central nervous system (CNS) perivascular epithelioid cell tumor (PEComa) in a middle-aged female patient. The tumor occurred in suprasellar location with secondary extension into the sella turcica. The patient presented with intracranial hemorrhage and an altered level of consciousness. The tumor had morphologic features matching those of other previously described TFE3-translocated PEComas, including epithelioid morphology, diffuse and strong nuclear immunoreactivity for TFE3, and minimal staining with myoid markers. The TFE3 break-apart FISH testing showed a slight splitting of one of the TFE3 signals in 49.5 % of nuclei. This case illustrates that PEComas should be added to the growing list of mesenchymal tumors that can be encountered in the CNS and specifically in the vicinity of the pituitary gland. The recognition of this entity is of significance given their underlying pathogenesis and possible management implications.

Indexed as

Basic Helix-Loop-Helix Leucine Zipper Transcription FactorsBiomarkers, TumorBrain NeoplasmsFemaleHumansImmunohistochemistryIn Situ Hybridization, FluorescenceMiddle AgedPerivascular Epithelioid Cell NeoplasmsSella TurcicaTranslocation, GeneticBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsBiomarkers, TumorTFE3 protein, humanFISHNonfunctioning sellar massPEComaPituitary adenomaTFE3

Identifiers

PMID27189222
OpenAlexW2398988042

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.