ReviewEMBO molecular medicine2016
The impact of genome-wide association studies on the pathophysiology and therapy of cardiovascular disease.
Review in EMBO molecular medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06362278 (A Multi-omics Study of Patients With Premature Coronary Artery Disease in the Absence of Common Risk Factors), which is not on this map. Cited by 89 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multi-omics Study of Patients With Premature Coronary Artery Disease in the Absence of Common Risk Factors
Who cites it
89 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Ancestry- and Age-Dependent Effects of NOS3 Polymorphisms on Coronary Heart Disease Risk: A Meta-analysis.Cardiovascular toxicology · 2025Pooled it
- Prioritization of causal genes for coronary artery disease based on cumulative evidence from experimental and in silico studies.Scientific reports · 2020Pooled it
- A Meta-Analysis on the Association BetweenFrontiers in physiology · 2020Pooled it
- Pioglitazone and the secondary prevention of cardiovascular disease. A meta-analysis of randomized-controlled trials.Cardiovascular diabetology · 2017Pooled it
- Clinical implementation of polygenic risk scores based on GWAS in the management of hypertension among Asian populations.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- EchoVisuALL: From Echocardiography to Gene Discovery.bioRxiv : the preprint server for biology · 2026Article
- Identification of novel and known variants inFrontiers in cardiovascular medicine · 2026Article
- Selected Genes Associated With CVD-Related Diseases, Pathways, and Nutrigenetics.Journal of lipid and atherosclerosis · 2026Review
- Correlation between ApoE gene polymorphisms and the prognosis of coronary artery disease in patients undergoing percutaneous coronary intervention.BMC cardiovascular disorders · 2025Article
- Trans-omics analyses identify the biochemical network of LPCAT1 associated with coronary artery disease.Biomarker research · 2025Article
- Genomic and Precision Medicine Approaches in Atherosclerotic Cardiovascular Disease: From Risk Prediction to Therapy-A Review.Biomedicines · 2025Review
- The relationship of genetic signature for cardiometabolic risk with biomarkers of inflammatory and oxidative stress in diabetic patients.BMC endocrine disorders · 2025Article
- Breaking binary in cardiovascular disease risk prediction.NPJ cardiovascular health · 2025Review
- A Spotlight on PLGA-based Nanoparticles: Pioneering a New Era in the Therapeutics of Cardiovascular Disorders.Current pharmaceutical design · 2025Review
- The Impact of Single Nucleotide Polymorphisms and Other Mechanisms on Aspirin Resistance.Cardiovascular & hematological disorders drug targets · 2025Review
- Genetic associations of cardiovascular risk genes in European patients with coronary artery spasm.Clinical research in cardiology : official journal of the German Cardiac Society · 2024Article
- Clinical and genetic associations of asymmetric apical and septal left ventricular hypertrophy.European heart journal. Digital health · 2024Article
- Genome-wide association study of therapeutic response to statin drugs in cardiovascular disease.Scientific reports · 2024Article
- Beyond Natriuretic Peptides: Unveiling the Power of Emerging Biomarkers in Heart Failure.Biomolecules · 2024Review
- Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiovascular diseases are leading causes for death worldwide. Genetic disposition jointly with traditional risk factors precipitates their manifestation. Whereas the implications of a positive family history for individual risk have been known for a long time, only in the past few years have genome-wide association studies (GWAS) shed light on the underlying genetic variations. Here, we review these studies designed to increase our understanding of the pathophysiology of cardiovascular diseases, particularly coronary artery disease and myocardial infarction. We focus on the newly established pathways to exemplify the translation from the identification of risk-related genetic variants to new preventive and therapeutic strategies for cardiovascular disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.