Evidence map›Paper›PMID 27188951›Full record

ArticleAmerican journal of epidemiology2016

Cost-Effectiveness of Pertussis Vaccination During Pregnancy in the United States.

Katherine E Atkins, Meagan C Fitzpatrick, Alison P Galvani, Jeffrey P Townsend

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 3 pooled it
6.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Trial
  5. Maternal vaccination-current status, challenges, and opportunities.The journal of obstetrics and gynaecology research · 2023
    Review
  6. Article
  7. Whole-Cell and Acellular Pertussis Vaccine: Reflections on Efficacy.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Katherine E Atkins
Meagan C Fitzpatrick
Alison P Galvani
Jeffrey P Townsend

Funding

YALE BIOMEDICAL SUPERCOMPUTER: NEUROSCIENCES10RR019895 · NCRR · YALE UNIVERSITY · PI WILLIAMS, KENNETH ROBERT · 2004 to 2004
$1.6M
High Performance Computing Instrumentation for Yale University Biomedical HPC CenS10RR029676 · NCRR · YALE UNIVERSITY · PI BJORNSON, ROBERT DEAN · 2011 to 2011
$588k
NCRR NIH HHS S10 RR019895NCRR NIH HHS S10 RR029676
6 · The paper itself

Abstract

Vaccination against pertussis has reduced the disease burden dramatically, but the most severe cases and almost all fatalities occur in infants too young to be vaccinated. Recent epidemiologic evidence suggests that targeted vaccination of mothers during pregnancy can reduce pertussis incidence in their infants. To evaluate the cost-effectiveness of antepartum maternal vaccination in the United States, we created an age-stratified transmission model, incorporating empirical data on US contact patterns and explicitly modeling parent-infant exposure. Antepartum maternal vaccination incurs costs of $114,000 (95% prediction interval: 82,000, 183,000) per quality-adjusted life-year, in comparison with the strategy of no adult vaccination, and is cost-effective in the United States according to World Health Organization criteria. By contrast, vaccinating a second parent is not cost-effective, and vaccination of either parent postpartum is strongly dominated by antepartum maternal vaccination. Nonetheless, postpartum vaccination of mothers who were not vaccinated antepartum improves upon the current recommendation of untargeted adult vaccination. Additionally, the temporary direct protection of the infant due to maternal antibody transfer has efficacy for infants comparable to that conferred to toddlers by the full primary vaccination series. Efficient protection against pertussis for infants begins before birth. We highly recommend antepartum vaccination for as many US mothers as possible.

Indexed as

AdultAge FactorsCost-Benefit AnalysisDiphtheria-Tetanus-acellular Pertussis VaccinesFemaleHumansImmunization ScheduleInfantInfant, NewbornModels, EconometricPregnancyQuality-Adjusted Life YearsUnited StatesWhooping CoughDiphtheria-Tetanus-acellular Pertussis Vaccinescost-effectivenessdynamic transmission modelmaternal antibody transfermaternal immunizationpertussissocial contact patternsvaccine policywhooping cough

Identifiers

PMID27188951
PMCPMC4908210
OpenAlexW2356058348

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.