Evidence map›Paper›PMID 27188891›Full record

ArticleBMC infectious diseases2016

Increased concentrations of soluble B7-H3 and interleukin 36 in bronchoalveolar lavage fluid of Children with Mycoplasma pneumoniae pneumonia.

Zhengrong Chen, Xin Zhao, Xinxing Zhang, Guangbo Zhang, Huiming Sun, Wujun Jiang, Yuqing Wang, Canhong Zhu, Wei Ji, Yongdong Yan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Interleukin-36: Structure, Signaling and Function.Advances in experimental medicine and biology · 2021
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Zhengrong ChenDepartment of Respiratory Disease, Children's Hospital of Soochow University, Soochow University, Suzhou, China.
Xin ZhaoGeneral surgery department, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.
Xinxing ZhangDepartment of Respiratory Disease, Children's Hospital of Soochow University, Soochow University, Suzhou, China.
Guangbo ZhangClinical Immunology Laboratory, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.
Huiming SunDepartment of Respiratory Disease, Children's Hospital of Soochow University, Soochow University, Suzhou, China.
Wujun JiangDepartment of Respiratory Disease, Children's Hospital of Soochow University, Soochow University, Suzhou, China.
Yuqing WangDepartment of Respiratory Disease, Children's Hospital of Soochow University, Soochow University, Suzhou, China.
Canhong ZhuDepartment of Respiratory Disease, Children's Hospital of Soochow University, Soochow University, Suzhou, China.
Wei JiDepartment of Respiratory Disease, Children's Hospital of Soochow University, Soochow University, Suzhou, China. szdxjiwei@163.com.
Yongdong YanDepartment of Respiratory Disease, Children's Hospital of Soochow University, Soochow University, Suzhou, China. yyd3060@163.com.
Soochow University · CNFirst Affiliated Hospital of Soochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe purpose of this study is to explore the correlations of interleukin 36 (IL-36) and Soluble B7-H3 (sB7-H3) levels in bronchoalveolar lavage fluid (BALF) with clinical characteristics and laboratory findings.

methodsA total of 35 children with M. pneumnoiae pneumonia (MPP) and 15 control subjects were enrolled. BALF concentrations of sB7-H3 and IL-36 were detected using enzyme-linked immunosorbent assays and clinical profiles of children with MPP were obtained.

resultsChildren with MPP had significantly higher levels of sB7-H3 and IL-36 compared to control subjects (both P < 0.05). Meanwhile, children with pleural effusion had significantly higher levels of sB7-H3 and IL-36 compared to children without pleural effusion (both P < 0.05). BALF concentration of sB7-H3 was strongly associated with concentration of IL-36 (r = 0.796, P < 0.0001) and sB7-H3 was correlated with duration of fever (r = 0.427, P = 0.11) and length of stay (r = 0.345, P = 0.043). Both concentrations of sB7-H3 and IL-36 were significantly decreased in convalescent phase after treatment (both P < 0.05).

conclusionBoth soluble B7-H3 and IL-36 may play an important role in pathogenesis of M. pneumoniae infection and sB7-H3 could be useful as a prognostic predictor or biomarker of MPP.

Indexed as

AdolescentB7 AntigensBiomarkersBronchoalveolar Lavage FluidChildChild, PreschoolEnzyme-Linked Immunosorbent AssayFemaleHumansInfantInterleukin-1MaleMycoplasma pneumoniaePneumonia, MycoplasmaB7 AntigensBiomarkersCD276 protein, humanInterleukin-1interleukin 36, humanB7-H3Bronchoalveolar lavage fluidChildrenInterleukin 36Mycoplasma pneumoniae pneumonia

Identifiers

PMID27188891
PMCPMC4869194
OpenAlexW2396047680

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.