Evidence map›Paper›PMID 27188686›Full record

ReviewNature reviews. Disease primers2016

Cerebral palsy.

H Kerr Graham, Peter Rosenbaum, Nigel Paneth, Bernard Dan, Jean-Pierre Lin, Diane L Damiano, Jules G Becher, Deborah Gaebler-Spira, Allan Colver, Dinah S Reddihough and 2 more

10 registry-linked trialsOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Disease primers, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 10 registered trials, which are not on this map. Cited by 451 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
451citing papers in PubMed, 14 pooled it
38.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03744884 naunknown statusnot on this mapstarted 2018, after this paper: background citation

Movement Impairment Characterization and Rehabilitation for Spastic/Dystonic Cerebral Palsy Using Robotic Haptic Feedback in Virtual Reality

TypeinterventionalSponsorUniversity of Illinois at Urbana-ChampaignRan2018 to 2021Enrolled68ConditionsCerebral Palsy, Mixed, Cerebral Palsy, SpasticArmsForce efforts with haptic feedback in virtual reality.
NCT04237506 nacompletednot on this mapstarted 2017, after this paper: background citation

Targeted Ballet Class for Increased Range of Motion and Stretch Reflex Regulation in Cerebral Palsy

TypeinterventionalSponsorCitlali Lopez-OrtizRan2017 to 2021Enrolled6ConditionsCerebral PalsyArmsTargeted ballet dance
NCT04612049 naterminatednot on this mapstarted 2021, after this paper: background citation

Immersive Virtual Reality for Visuo-motor Integration Skill Assessment in Children With Hemiplegia

TypeinterventionalSponsorNortheastern UniversityRan2021 to 2021Enrolled12ConditionsCerebral Palsy, HemiplegiaArmsImmersive virtual reality visuo-motor skill assessment
NCT06330922 recruitingnot on this mapstarted 2024, after this paper: background citation

Muscle-tendon Pathology, Metabolic Dysregulation and Chronic Inflammation in Adolescents and Young Adults With Moderate to Severe Spastic Cerebral Palsy

TypeobservationalSponsorUniversity of GrazRan2024 to 2027Enrolled50ConditionsCerebral Palsy, SpasticArmsCardiorespiratory fitness training
NCT06355869 completednot on this mapstarted 2021, after this paper: background citation

Repeatability of Gait of Children With Spastic Cerebral Palsy in Different Walking Conditions

TypeobservationalSponsorUniversitaire Ziekenhuizen KU LeuvenRan2021 to 2023Enrolled10ConditionsSpastic Cerebral PalsyArmsrepeated 3D gait-analysis
NCT06477224 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Effects of Scooter Board Activities on Neck Control and Dysphagia in Children With Cerebral Palsy

TypeinterventionalSponsorRiphah International UniversityRan2024 to 2024Enrolled22ConditionsCerebral Palsy (CP)ArmsScooter Board Activities, Routine Physical Therapy
NCT06586125 completednot on this mapstarted 2023, after this paper: background citation

The Impact of Virtual Reality on Powered Mobility in Patients With Neuromotor Disabilities: a Feasibility Study

TypeobservationalSponsorAzienda Usl di BolognaRan2023 to 2025Enrolled10ConditionsCerebral Palsy Infantile, Neuromuscular Diseases in ChildrenArmsPowered Mobility Training
NCT06624280 completednot on this mapstarted 2024, after this paper: background citation

Does Orthopedic Surgery Improve Gait Efficiency in Children With Cerebral Palsy? A Retrospective Study

TypeobservationalSponsorAzienda USL Reggio Emilia - IRCCSRan2024 to 2024Enrolled78ConditionsCerebral Palsy (CP)Armssingle-event multilevel surgery
NCT06785220 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

The Effects of Oral Facial Facilitation and Oral Motor Therapy in Dysphagia with Spastic Cerebral Palsy

TypeinterventionalSponsorKafrelsheikh UniversityRan2025 to 2025Enrolled13ConditionsDysphagia, Spastic Cerebral Palsy (sCP)ArmsORAL FACIAL FACILITATION, ORAL MOTOR THERAPY, ORAL FACIAL FACILITATION WITH ORAL MOROR THERAY
NCT07031609 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Spastik Hemiparetik Serebral Palsili Bireylerde Robotik Destekli Yürüyüş Eğitimi, Hidroterapi ve Konvansiyoel Fizyoterapi Yöntemlerinin Kas Kuvveti, Denge, Fonksiyonel Mobilite ve Ruhsal Uyum Üzerindeki Etkileri

TypeinterventionalSponsorIstanbul Arel UniversityRan2025 to 2026Enrolled45ConditionsCerebral PalsyArmsRobot-assisted gait training using Lokomat, Hydrotherapy, Conventional Physiotherapy
3 · Its place in the literature

Who cites it

451 citing papers in PubMed, 14 syntheses or guidelines pooled it, 933 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Systematic review and network meta-analysis of robot-assisted gait training on lower limb function in patients with cerebral palsy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
    Pooled it
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Trial

391 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 10 institutions in 6 countries.

H Kerr GrahamOrthopaedic Department, The Royal Children's Hospital, 50 Flemington Road, Parkville, Victoria 3052, Australia.
Peter RosenbaumCanChild Centre, McMaster University, Hamilton, Ontario, Canada.
Nigel PanethDepartments of Epidemiology, Biostatistics and Pediatrics, and Human Development, College of Human Medicine, Michigan State University, East Lansing, Michigan, USA.
Bernard DanDepartment of Neurology, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Jean-Pierre LinComplex Motor Disorders Service, Evelina Children's Hospital, London, UK.
Diane L DamianoRehabilitation Medicine Department, National Institutes of Health, Bethesda, Maryland, USA.
Jules G BecherDepartment of Rehabilitation Medicine, VU University Medical Center, Amsterdam, The Netherlands.
Deborah Gaebler-SpiraDepartment of Physical Medicine and Rehabilitation and Pediatrics, Feinberg Northwestern School of Medicine, Rehabilitation Institute of Chicago, Chicago, Illinois, USA.
Allan ColverInstitute of Health and Society, Newcastle University, Newcastle upon Tyne, UK.
Dinah S ReddihoughDevelopmental Disability and Rehabilitation Research, Murdoch Childrens Research Institute, The Royal Children's Hospital, Victoria, Australia.
Kylie E CromptonDevelopmental Disability and Rehabilitation Research, Murdoch Childrens Research Institute, The Royal Children's Hospital, Victoria, Australia.
Richard L LieberRehabilitation Institute of Chicago, Chicago, Illinois, USA.
Murdoch Children's Research Institute · AUShirley Ryan AbilityLab · USAmsterdam UMC Location VUmc · NLEvelina London Children's Healthcare · GBMcMaster University · CAMichigan State University · USNational Institutes of Health · USNewcastle University · GBRoyal Children's Hospital · AUUniversité Libre de Bruxelles · BE

Funding

Intramural NIH HHS Z99 CL999999
6 · The paper itself

Abstract

Cerebral palsy is the most common cause of childhood-onset, lifelong physical disability in most countries, affecting about 1 in 500 neonates with an estimated prevalence of 17 million people worldwide. Cerebral palsy is not a disease entity in the traditional sense but a clinical description of children who share features of a non-progressive brain injury or lesion acquired during the antenatal, perinatal or early postnatal period. The clinical manifestations of cerebral palsy vary greatly in the type of movement disorder, the degree of functional ability and limitation and the affected parts of the body. There is currently no cure, but progress is being made in both the prevention and the amelioration of the brain injury. For example, administration of magnesium sulfate during premature labour and cooling of high-risk infants can reduce the rate and severity of cerebral palsy. Although the disorder affects individuals throughout their lifetime, most cerebral palsy research efforts and management strategies currently focus on the needs of children. Clinical management of children with cerebral palsy is directed towards maximizing function and participation in activities and minimizing the effects of the factors that can make the condition worse, such as epilepsy, feeding challenges, hip dislocation and scoliosis. These management strategies include enhancing neurological function during early development; managing medical co-morbidities, weakness and hypertonia; using rehabilitation technologies to enhance motor function; and preventing secondary musculoskeletal problems. Meeting the needs of people with cerebral palsy in resource-poor settings is particularly challenging.

Indexed as

Activities of Daily LivingCerebral PalsyEarly DiagnosisGaitHumansPremature BirthQuality of Life

Identifiers

PMID27188686
PMCPMC9619297
OpenAlexW4211074903

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

and 4 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.