ArticleScientific reports2016
The contribution of inflammasome components on macrophage response to surface nanotopography and chemistry.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 42 citations in OpenAlex.
- Review
- The inflammasome in biomaterial-driven immunomodulation.Journal of tissue engineering and regenerative medicine · 2022Review
- Prevention of the foreign body response to implantable medical devices by inflammasome inhibition.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The Impact of Engineered Silver Nanomaterials on the Immune System.Nanomaterials (Basel, Switzerland) · 2020Review
- Field Deployable Method for Gold Detection Using Gold Pre-Concentration on Functionalized Surfaces.Sensors (Basel, Switzerland) · 2020Article
- Macrophage and Fibroblast Interactions in Biomaterial-Mediated Fibrosis.Advanced healthcare materials · 2019Review
- Perspective on Plasma Polymers for Applied Biomaterials Nanoengineering and the Recent Rise of Oxazolines.Materials (Basel, Switzerland) · 2019Review
- Exploratory Testing of Diatom Silica to Map the Role of Material Attributes on Cell Fate.Scientific reports · 2017Article
- The Influence of Radiotherapy on AIM2 Inflammasome in Radiation Pneumonitis.Inflammation · 2016Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Implantable devices have become an established part of medical practice. However, often a negative inflammatory host response can impede the integration and functionality of the device. In this paper, we interrogate the role of surface nanotopography and chemistry on the potential molecular role of the inflammasome in controlling macrophage responses. To achieve this goal we engineered model substrata having precisely controlled nanotopography of predetermined height and tailored outermost surface chemistry. Bone marrow derived macrophages (BMDM) were harvested from genetically engineered mice deficient in the inflammasome components ASC, NLRP3 and AIM2. These cells were then cultured on these nanoengineered substrata and assessed for their capacity to attach and express pro-inflammatory cytokines. Our data provide evidence that the inflammasome components ASC, NLRP3 and AIM2 play a role in regulating macrophage adhesion and activation in response to surface nanotopography and chemistry. The findings of this paper are important for understanding the inflammatory consequences caused by biomaterials and pave the way to the rational design of future implantable devices having controlled and predictable inflammatory outcomes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.