ArticleScientific reports2016
Paneth Cell in Adenomas of the Distal Colorectum Is Inversely Associated with Synchronous Advanced Adenoma and Carcinoma.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Inflammatory bowel disease-associated colorectal dysplasia: the expanding morphologic landscape and diagnostic challenges.Virchows Archiv : an international journal of pathology · 2026Review
- Tcf4 regulates secretory cell fate decisions in the small intestine and colon tumors: insights from transcriptomic, histological, and microbiome analyses.Stem cell research & therapy · 2025Article
- [Paneth Cell Carcinoma of the Stomach].The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2022Article
- Article
- The histomorphological and molecular landscape of colorectal adenomas and serrated lesions.Pathologica · 2021Review
- Paneth cell-derived growth factors support tumorigenesis in the small intestine.Life science alliance · 2021Article
- Non-conventional dysplastic subtypes in inflammatory bowel disease: a review of their diagnostic characteristics and potential clinical implications.Journal of pathology and translational medicine · 2021Review
- Incidental morphological findings in colorectal adenomas.Histopathology · 2021Review
- Colorectal sessile serrated lesion with large size or synchronous neoplasm: a prospective study.European journal of gastroenterology & hepatology · 2020Article
- Metaplastic Paneth Cells in Extra-Intestinal Mucosal Niche Indicate a Link to Microbiome and Inflammation.Frontiers in physiology · 2020Review
- Gastroesophageal junction Paneth cell carcinoma with extensive cystic and secretory features - case report and literature review.Diagnostic pathology · 2019Review
- Extensive Paneth cell metaplasia in an ovarian Krukenberg tumor: report of an unusual case and literature review.Journal of surgical case reports · 2018Article
- Two-photon microscopy of Paneth cells in the small intestine of live mice.Scientific reports · 2018Article
- Inflammation and Colorectal Cancer.Current colorectal cancer reports · 2017Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
Recent studies have linked appearance of Paneth cells in colorectal adenomas to adenoma burden and male gender. However, the clinical importance of Paneth cells' associations with synchronous advanced adenoma (AA) and colorectal carcinoma (CRC) is currently unclear. We performed a comprehensive case-control study using 1,900 colorectal adenomas including 785 from females, and 1,115 from males. We prospectively reviewed and recorded Paneth cell status in the colorectal adenomas consecutively collected between February 2014 and June 2015. Multivariable logistic regression analyses revealed that, in contrast to the adenomas without Paneth cells, the Paneth cell-containing adenomas at distal colorectum were inversely associated with presence of a synchronous AA or CRC (odds ratio [OR] 0.39, P = 0.046), whereas no statistical significance was reached for Paneth cell-containing proximal colorectal adenomas (P = 0.33). Synchronous AA and CRC were significantly associated with older age (60 + versus <60 years, OR 1.60, P = 0.002), male gender (OR 1.42, P = 0.021), and a history of AA or CRC (OR 2.31, P < 0.001). However, synchronous CRC was not associated with Paneth cell status, or a history of AA or CRC. Paneth cell presence in the adenomas of distal colorectum may be a negative indicator for synchronous AA and CRC, and seems to warrant further studies.
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