ArticleEuropean journal of nutrition2017
Effects of intrauterine growth retardation and Bacillus subtilis PB6 supplementation on growth performance, intestinal development and immune function of piglets during the suckling period.
Article in European journal of nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 63 citations in OpenAlex.
- Multi-omics analysis reveals Parabacteroides distasonis and Kineothrix alysoides as potential key bacterial species associated with anemia in sows.Journal of animal science and biotechnology · 2026Article
- Single-Cell Transcriptome and Microbiome Profiling Uncover Ileal Immune Impairment in Intrauterine Growth-Retarded Piglets.Current pharmaceutical design · 2026Article
- Dietary supplementation with Bacillus-based probiotic improves gut health in the weaned piglets challenged by rotavirus.Journal of animal science and biotechnology · 2025Article
- Connecting Molecular Characteristics of Intrauterine Growth-Retarded Piglets to Targeted Nutritional Interventions: A Review.Animals : an open access journal from MDPI · 2025Review
- Weaning Stress Aggravates Defense Response and the Burden of Protein Metabolism in Low-Birth-Weight Piglets.Animals : an open access journal from MDPI · 2025Article
- Dietary Supplementation with Fermented Milk Improves Growth Performance and Intestinal Functions in Intrauterine Growth-Restricted Piglets.Animals : an open access journal from MDPI · 2025Article
- The characteristics, influence factors, and regulatory strategies of growth retardation in ruminants: a review.Frontiers in veterinary science · 2025Review
- Dietary supplementation withFrontiers in veterinary science · 2025Article
- Live Multi-Strain Probiotics Enhance Growth Performance by Regulating Intestinal Morphology and Microbiome Population in Weaning Piglets.Microorganisms · 2024Article
- Endoplasmic Reticulum Stress Contributes to Intestinal Injury in Intrauterine Growth Restriction Newborn Piglets.Animals : an open access journal from MDPI · 2024Article
- Dietary supplementation with dihydroartemisinin improves intestinal barrier function in weaned piglets with intrauterine growth retardation by modulating the gut microbiota.Journal of animal science · 2024Article
- Review
- Gut Microbiota, Inflammation, and Probiotic Supplementation in Fetal Growth Restriction-A Comprehensive Review of Human and Animal Studies.Life (Basel, Switzerland) · 2023Review
- Article
- Joint Application ofVeterinary sciences · 2022Article
- Restored intestinal integrity, nutrients transporters, energy metabolism, antioxidative capacity and decreased harmful microbiota were associated with IUGR piglet's catch-up growth before weanling.Journal of animal science and biotechnology · 2022Article
- Effects of Multi-Strain Probiotics andAnimals : an open access journal from MDPI · 2022Article
- Nutrition and Immunity in Perinatal Hypoxic-Ischemic Injury.Nutrients · 2022Review
- Effects of ferulic acid on the growth performance, antioxidant capacity, and intestinal development of piglets with intrauterine growth retardation.Journal of animal science · 2022Article
- Curcumin and Intestinal Oxidative Stress of Pigs With Intrauterine Growth Retardation: A Review.Frontiers in nutrition · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this study was to investigate the effects of intrauterine growth retardation (IUGR) and Bacillus subtilis PB6 supplementation in formula milk (FORM) on growth performance, intestinal development and immune function of neonates using a porcine model.
methodsFourteen pairs of normal birth weight and IUGR piglets (7 days old) were randomly assigned to receive FORM or FORM supplemented with B. subtilis PB6 (FORM-BsPB6) for a period of 21 days. Blood samples, intestinal tissues and digesta were collected at necropsy and analysed for morphology, digestive enzyme activities, immune cell abundance, expression of genes associated with innate immunity and barrier function and microbial populations.
resultsRegardless of diet, IUGR significantly decreased average daily dry matter intake and average daily weight gain (P < 0.05). Moreover, IUGR significantly decreased plasma concentrations of immunoglobulin A, interleukin 1β, count and percentage of blood lymphocytes (P < 0.05). Meanwhile, IUGR markedly decreased villous height and maltase activity, as well as mRNA abundance of Toll-like receptor 9 and Toll-interacting protein in the ileum (P < 0.05). Regardless of body weight, FORM-BsPB6 markedly decreased the feed conversion ratio (P < 0.05), due to better intestinal development, as indicated by increased villous height (P < 0.05), activities of maltase and sucrase in the intestine (P < 0.10). Moreover, both mRNA and protein abundances of zonula occludens-1 and claudin-1 in the ileum as well as the copy number of Bacillus in colonic digesta were increased (P < 0.05) in piglets fed FORM-BsPB6 relative to FORM.
conclusionThe results of this study indicate that IUGR delayed growth, intestinal development and immune function of piglets, while FORM-BsPB6 improved digestive capability and intestinal barrier function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.