Evidence map›Paper›PMID 27187847›Full record

ArticlePsychosomatic medicine2016

Major Depression and Long-Term Survival of Patients With Heart Failure.

Kenneth E Freedland, Michael J Hesseler, Robert M Carney, Brian C Steinmeyer, Judith A Skala, Victor G Dávila-Román, Michael W Rich

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychosomatic medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Trial
  4. Trial
  5. An Intervention to Improve Physical Function and Caregiver Perceptions in Family Caregivers of Persons With Heart Failure.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2020
    Trial
  6. Trial
  7. Observational
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Observational
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Kenneth E FreedlandFrom the Departments of Psychiatry (Freedland, Carney, Steinmeyer) and Medicine (Hesseler, Dávila-Román, Rich), Washington University School of Medicine, St Louis, Missouri; and Palliative Care Department (Skala), Veterans Administration Medical Center, St Louis, Missouri.
Michael J Hesseler
Robert M Carney
Brian C Steinmeyer
Judith A Skala
Victor G Dávila-Román
Michael W Rich
John Cochran VA Medical Center · US

Funding

DEPRESSION AND HEART FAILURE IN THE ELDERLYR01MH051419 · NIMH · WASHINGTON UNIVERSITY · PI FREEDLAND, KENNETH E · 1993 to 1999
–
NIMH NIH HHS R01 MH051419
6 · The paper itself

Abstract

objectivesPrevious studies have found that depression predicts all-cause mortality in heart failure (HF), but little is known about its effect on long-term survival. This study examined the effects of depression on long-term survival in patients with HF.

methodsPatients hospitalized with HF (n = 662) at an urban academic medical center were enrolled in a prospective cohort study between January 1994 and July 1999. Depression was assessed on a structured interview during the index hospitalization and on quarterly interviews for 1 year after discharge. Patients were classified at index as having Diagnostic and Statistical Manual, Fourth Edition major depressive disorder (n = 131), minor depression (n = 106), or no depression (n = 425). Clinical data and the National Death Index were used to identify date of death or last known contact through December 19, 2014, up to 20 years after the index hospitalization. The main outcome was time from enrollment to death from any cause.

resultsA total of 617 (94.1%) patients died during the follow-up period. Major depressive disorder was associated with higher all-cause mortality compared with no depression (adjusted hazard ratio = 1.64, 95% confidence interval = 1.27-2.11, p = .0001). This association was stronger than that of any of the established predictors of mortality that were included in the fully adjusted model. Patients with persistent or worsening depressive symptoms during the year after discharge were at greatest risk for death. The association between minor depression and survival was not significant.

conclusionsMajor depression is an independent risk factor for all-cause mortality in patients with HF. Its effect persists for many years after the diagnosis of depression.

Indexed as

AgedAged, 80 and overComorbidityDepressionFemaleFollow-Up StudiesHeart FailureHumansMajor Depressive DisorderMaleMiddle Aged

Identifiers

PMID27187847
PMCPMC5067963
OpenAlexW2395819995

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.