ArticlePsychosomatic medicine2016
Associations Among Child Abuse, Depression, and Interleukin-6 in Pregnant Adolescents: Paradoxical Findings.
Article in Psychosomatic medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Early life adversity exposure and circulating markers of inflammation in children and adolescents: A systematic review and meta-analysis.Brain, behavior, and immunity · 2020Pooled it
- Inflammatory Stress Response During Pregnancy as a Connecting Link in Intergenerational Risk Cascades.Developmental psychobiology · 2026Article
- Maternal adversity and peripheral proinflammatory cytokine concentrations in pregnancy.Brain, behavior, & immunity - health · 2026Article
- Maternal depression with and without a history of childhood maltreatment and newborn white matter microstructure.Psychological medicine · 2026Article
- Estimating the associations between women's maltreatment in childhood and inflammatory biomarker levels prior to and during pregnancy.PloS one · 2025Article
- A Brief Historic Review of Research on Early Life Stress and Inflammation across the Lifespan.Neuroimmunomodulation · 2025Review
- The interaction of second trimester prenatal maternal inflammation and psychosocial stress on offspring depressive symptoms in adolescence.Brain behavior and immunity integrative · 2024Article
- Childhood Maltreatment and Perinatal Complications: A Scoping Review of Official Health Data.Trauma, violence & abuse · 2024Article
- Inflammatory burden of adolescents with childhood maltreatment: results from baseline data of a school cohort.European child & adolescent psychiatry · 2024Article
- Is There an Inflammatory Profile of Perinatal Depression?Current psychiatry reports · 2023Review
- Maternal early life stress is associated with pro-inflammatory processes during pregnancy.Brain, behavior, and immunity · 2023Article
- Exposure to childhood maltreatment and systemic inflammation across pregnancy: The moderating role of depressive symptomatology.Brain, behavior, and immunity · 2022Article
- Childhood adversity, prenatal depression, and maternal inflammation across pregnancy.Obstetric medicine · 2022Article
- Stress-Related Mental Health Disorders and Inflammation in Pregnancy: The Current Landscape and the Need for Further Investigation.Frontiers in psychiatry · 2022Review
- Integrative Review of Early Life Adversity and Cortisol Regulation in Pregnancy.Journal of obstetric, gynecologic, and neonatal nursing : JOGNN · 2021Review
- Maternal Distress and Offspring Neurodevelopment: Challenges and Opportunities for Pre-clinical Research Models.Frontiers in human neuroscience · 2021Article
- Potential biomarkers of emotional stress induced neurodegeneration.eNeurologicalSci · 2020Review
- Maternal History of Adverse Childhood Experiences and Ambulatory Blood Pressure in Pregnancy.Psychosomatic medicine · 2020Article
- Prenatal risk factors for internalizing and externalizing problems in childhood.World journal of pediatrics : WJP · 2020Review
- DNA methylation patterns in T lymphocytes are generally stable in human pregnancies but CD3 methylation is associated with perinatal psychiatric symptoms.Brain, behavior, & immunity - health · 2020Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveLimited data exist on child abuse-related immune variation during pregnancy, despite implications for maternal and infant health and extensive data showing that abuse history and depression are related to increased inflammation in other populations. This study examined associations among child abuse, depression, circulating levels of inflammatory markers, and perinatal health in pregnant adolescents, a group at high risk for childhood abuse and poor birth outcomes.
methodsPregnant teenagers (n = 133; 14-19 years; 89.5% Latina) reported on abuse and depression and had two blood draws (24-27 and 34-37 gestational weeks, second and third trimesters, respectively) for interleukin-6 (IL-6) and C-reactive protein; birth outcomes were collected.
resultsAbuse and depression interacted to predict higher IL-6 at second trimester (B = 0.006, p = .011) such that severely abused adolescents with high depression had higher IL-6 relative to severely abused adolescents with low depression; depression did not differentiate IL-6 levels for those with low abuse severity. Abuse and IL-6 also interacted to predict gestational age at birth (B = 0.004, p = .040) such that those with low abuse and high IL-6 and those with high abuse and low IL-6 had infants with earlier gestational age at birth. Cortisol at the second trimester mediated the association between IL-6 and gestational age at birth (indirect effect estimate=-0.143, p < .039).
conclusionsDepression severity distinguished IL-6 levels among more severely abused pregnant Latina adolescents, but it was unrelated to IL-6 among less severely abused adolescents. Cortisol explained the relationship between IL-6 and earlier gestational age at birth. Multiple adversities and inflammation may influence birth outcomes and potentially affect intergenerational health.
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