Evidence map›Paper›PMID 27187845›Full record

Trial reportPsychosomatic medicine

Pilot Randomized Study of a Gratitude Journaling Intervention on Heart Rate Variability and Inflammatory Biomarkers in Patients With Stage B Heart Failure.

Laura S Redwine, Brook L Henry, Meredith A Pung, Kathleen Wilson, Kelly Chinh, Brian Knight, Shamini Jain, Thomas Rutledge, Barry Greenberg, Alan Maisel and 1 more

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psychosomatic medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 35 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01615094 completednot on this map

BNP and Neuroimmune Characteristics of CHF and Depression (Competing Renewal)

TypeobservationalSponsorUniversity of California, San DiegoRan2011 to 2015Enrolled456ConditionsHeart Failure, Depression
NCT04800432 nacompletednot on this map

ADAPT+: Optimizing an Intervention to Promote Healthy Behaviors in Rural, Latino Youth With Obesity and Their Parents, Using Mindfulness Strategies

TypeinterventionalSponsorUniversity of South FloridaRan2021 to 2023Enrolled95ConditionsPediatric ObesityArmsADAPT+, EUC
3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  17. Position Statement on Women's Cardiovascular Health - 2022.Arquivos brasileiros de cardiologia · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Laura S RedwineFrom the Departments of Psychiatry (Redwine, Henry, Chinh, Jain, Rutledge), Family Medicine and Public Health (Pung, Wilson, Mills), and Medicine (Knight, Greenberg, Maisel), University of California, San Diego, California.
Brook L Henry
Meredith A Pung
Kathleen Wilson
Kelly Chinh
Brian Knight
Shamini Jain
Thomas Rutledge
Barry Greenberg
Alan Maisel
Paul J Mills

Funding

BNP and Neuroimmune Characteristics of CHF &DepressionR01HL073355 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILLS, PAUL J · 2005 to 2014
$5.6M
Vascular Biology ResearchT32HL007355 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI MCNAMARA, COLEEN A · 1985 to 2009
$2.6M
NHLBI NIH HHS R01 HL073355NHLBI NIH HHS T32 HL007355
6 · The paper itself

Abstract

objectiveStage B, asymptomatic heart failure (HF) presents a therapeutic window for attenuating disease progression and development of HF symptoms, and improving quality of life. Gratitude, the practice of appreciating positive life features, is highly related to quality of life, leading to development of promising clinical interventions. However, few gratitude studies have investigated objective measures of physical health; most relied on self-report measures. We conducted a pilot study in Stage B HF patients to examine whether gratitude journaling improved biomarkers related to HF prognosis.

methodsPatients (n = 70; mean [standard deviation] age = 66.2 [7.6] years) were randomized to an 8-week gratitude journaling intervention or treatment as usual. Baseline (T1) assessments included the six-item Gratitude Questionnaire, resting heart rate variability (HRV), and an inflammatory biomarker index. At T2 (midintervention), the six-item Gratitude Questionnaire was measured. At T3 (postintervention), T1 measures were repeated but also included a gratitude journaling task.

resultsThe gratitude intervention was associated with improved trait gratitude scores (F = 6.0, p = .017, η = 0.10), reduced inflammatory biomarker index score over time (F = 9.7, p = .004, η = 0.21), and increased parasympathetic HRV responses during the gratitude journaling task (F = 4.2, p = .036, η = 0.15), compared with treatment as usual. However, there were no resting preintervention to postintervention group differences in HRV (p values > .10).

conclusionsGratitude journaling may improve biomarkers related to HF morbidity, such as reduced inflammation; large-scale studies with active control conditions are needed to confirm these findings.

trial registrationClinicaltrials.govidentifier:NCT01615094.

Indexed as

Heart FailureOutcome Assessment, Health CarePersonal Narratives as TopicAgedBiomarkersFemaleHeart RateHumansInflammationMaleMiddle AgedPilot ProjectsPsychotherapySeverity of Illness IndexBiomarkers

Identifiers

PMID27187845
PMCPMC4927423

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.