ArticlePLoS medicine2016
The Clinical Challenge of Sepsis Identification and Monitoring.
Article in PLoS medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
120 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Lactate-enhanced-qSOFA (LqSOFA) score as a predictor of in-hospital mortality in patients with sepsis: systematic review and meta-analysis.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Pooled it
- Sepsis Alert Systems, Mortality, and Adherence in Emergency Departments: A Systematic Review and Meta-Analysis.JAMA network open · 2024Pooled it
- Pooled it
- Pooled it
- Sepsis prediction, early detection, and identification using clinical text for machine learning: a systematic review.Journal of the American Medical Informatics Association : JAMIA · 2022Pooled it
- Machine learning for the prediction of sepsis: a systematic review and meta-analysis of diagnostic test accuracy.Intensive care medicine · 2020Pooled it
- Pooled it
- Trial
- Deciphering sepsis molecular subtypes using large-scale data to identify subtype-specific drug repurposing.bioRxiv : the preprint server for biology · 2026Article
- Therapeutic Potential of Allicin in Multi-System Inflammatory Diseases.Current issues in molecular biology · 2026Review
- Sequential Application of Time-Stratified Demographic, Vital, Clinical-Laboratory, and Microbiology Variables for Accurate and Rapid Identification of Sepsis.Diseases (Basel, Switzerland) · 2026Article
- Selective detection of clinically relevant Gram-negative bacteria using a colistin-functionalized ISFET biosensor.BMC microbiology · 2026Article
- Lipopolysaccharide hydrolysis-targeting nano-chimeras detoxify endotoxin through specific adsorption and efficient degradation.Nature communications · 2026Article
- Impact of United Kingdom guidelines for stratification of risk in adult hospital inpatients identified with sepsis - an observational cohort study.BMC infectious diseases · 2026Observational
- Longitudinal blood transcriptome profiling reveals immune dynamics in sepsis.BMC infectious diseases · 2026Article
- Sepsis as a complex syndrome: Are combined biomarkers the future of diagnosis and prognosis? Clinical perspective.Immunology letters · 2026Review
- Raman Spectroscopy Can Identify Acute and Persistent Biochemical Changes in Leukocytes From Patients With COVID-19 and Non-COVID-19-Associated Sepsis.Biotechnology journal · 2025Article
- Review
- A novel scoring system for evaluating mortality risk of patients with sepsis during early hospitalization.BMC infectious diseases · 2025Article
- The Effect of Sepsis Recognition on Telemedicine Use in Rural Emergency Department Sepsis Treatment.Telemedicine journal and e-health : the official journal of the American Telemedicine Association · 2025Article
60 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Jean-Louis Vincent outlines why combinations of biomarkers will be central to the future of sepsis diagnosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.