ArticleThe ISME journal2017
Regulation of infection efficiency in a globally abundant marine Bacteriodetes virus.
Article in The ISME journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed.
- Detection and characterization of protein methylation in bacteriophages and their host,mSystems · 2026Article
- Isolation and characterization of TayeBlu, a novel bacteriophage ofMicrobiology spectrum · 2026Article
- Metabolome restructuring reveals distinct virocell infection strategies in bacteriophage-host interaction.ISME communications · 2026Article
- Warming disrupts infection patterns and primarily acceleratesISME communications · 2026Article
- Seasonal enhancement of the viral shunt catalyzes a subsurface oxygen maximum in the Sargasso Sea.Nature communications · 2025Article
- Virocell resource manipulation under nutrient limitation.mSystems · 2025Article
- Two novel polyvalent phages: a promising approach for cross-order pathogen control in aquaculture.Virology journal · 2025Article
- Article
- Comparative transcriptomes reveal differential effects on host metabolism reprogramming in two different pelagiphage-SAR11 infection systems.ISME communications · 2025Article
- Biodiversity of microorganisms in the Baltic Sea: the power of novel methods in the identification of marine microbes.FEMS microbiology reviews · 2024Review
- Environment-specific virocell metabolic reprogramming.The ISME journal · 2024Article
- Prediction and characterization of prophages of Stenotrophomonas maltophilia reveals a remarkable phylogenetic diversity of prophages.Scientific reports · 2023Article
- Protist impacts on marine cyanovirocell metabolism.ISME communications · 2022Article
- Nutrient driven transcriptional changes during phage infection in an aquatic Gammaproteobacterium.Environmental microbiology · 2022Article
- Interactions between bacterial and phage communities in natural environments.Nature reviews. Microbiology · 2022Review
- Characterization of a New and Efficient Polyvalent Phage InfectingMicroorganisms · 2021Article
- Revisiting the rules of life for viruses of microorganisms.Nature reviews. Microbiology · 2021Review
- Ecology and molecular targets of hypermutation in the global microbiome.Nature communications · 2021Article
- Tara Oceans: towards global ocean ecosystems biology.Nature reviews. Microbiology · 2020Review
- Genetically similar temperate phages form coalitions with their shared host that lead to niche-specific fitness effects.The ISME journal · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
Abstract
Bacteria impact humans, industry and nature, but do so under viral constraints. Problematically, knowledge of viral infection efficiencies and outcomes derives from few model systems that over-represent efficient lytic infections and under-represent virus-host natural diversity. Here we sought to understand infection efficiency regulation in an emerging environmental Bacteroidetes-virus model system with markedly different outcomes on two genetically and physiologically nearly identical host strains. For this, we quantified bacterial virus (phage) and host DNA, transcripts and phage particles throughout both infections. While phage transcriptomes were similar, transcriptional differences between hosts suggested host-derived regulation of infection efficiency. Specifically, the alternative host overexpressed DNA degradation genes and underexpressed translation genes, which seemingly targeted phage DNA particle production, as experiments revealed they were both significantly delayed (by >30 min) and reduced (by >50%) in the inefficient infection. This suggests phage failure to repress early alternative host expression and stress response allowed the host to respond against infection by delaying phage DNA replication and protein translation. Given that this phage type is ubiquitous and abundant in the global oceans and that variable viral infection efficiencies are central to dynamic ecosystems, these data provide a critically needed foundation for understanding and modeling viral infections in nature.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.