Evidence map›Paper›PMID 27187465›Full record

ReviewNutrients2016

Protein Intake and Muscle Health in Old Age: From Biological Plausibility to Clinical Evidence.

Francesco Landi, Riccardo Calvani, Matteo Tosato, Anna Maria Martone, Elena Ortolani, Giulia Savera, Emanuela D'Angelo, Alex Sisto, Emanuele Marzetti

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrients, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
119citing papers in PubMed, 13 pooled it
14.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

119 citing papers in PubMed, 13 syntheses or guidelines pooled it, 207 citations in OpenAlex.

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  7. Protein Intake and Sarcopenia in Older Adults: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022
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  14. Nutrients · 2024
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59 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Francesco LandiDepartment of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, L.go F. Vito 8, Rome 00168, Italy. francesco.landi@rm.unicatt.it.
Riccardo CalvaniDepartment of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, L.go F. Vito 8, Rome 00168, Italy. riccardo.calvani@gmail.com.
Matteo TosatoDepartment of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, L.go F. Vito 8, Rome 00168, Italy. matteo.tosato@rm.unicatt.it.
Anna Maria MartoneDepartment of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, L.go F. Vito 8, Rome 00168, Italy. annamariamartone@gmail.com.
Elena OrtolaniDepartment of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, L.go F. Vito 8, Rome 00168, Italy. eleort@gmail.com.
Giulia SaveraDepartment of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, L.go F. Vito 8, Rome 00168, Italy. giulia.savera@libero.it.
Emanuela D'AngeloDepartment of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, L.go F. Vito 8, Rome 00168, Italy. manud1983@yahoo.it.
Alex SistoDepartment of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, L.go F. Vito 8, Rome 00168, Italy. alexsisto@gmail.com.
Emanuele MarzettiDepartment of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, L.go F. Vito 8, Rome 00168, Italy. emarzetti@live.com.
Università Cattolica del Sacro Cuore · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The provision of sufficient amounts of dietary proteins is central to muscle health as it ensures the supply of essential amino acids and stimulates protein synthesis. Older persons, in particular, are at high risk of insufficient protein ingestion. Furthermore, the current recommended dietary allowance for protein (0.8 g/kg/day) might be inadequate for maintaining muscle health in older adults, probably as a consequence of "anabolic resistance" in aged muscle. Older individuals therefore need to ingest a greater quantity of protein to maintain muscle function. The quality of protein ingested is also essential to promoting muscle health. Given the role of leucine as the master dietary regulator of muscle protein turnover, the ingestion of protein sources enriched with this essential amino acid, or its metabolite β-hydroxy β-methylbutyrate, is thought to offer the greatest benefit in terms of preservation of muscle mass and function in old age.

Indexed as

AgedDietary ProteinsHumansLeucineMuscle ProteinsMuscle, SkeletalNutritional RequirementsNutritional StatusDietary ProteinsLeucineMuscle Proteinsamino acidanorexiafrailtyleucinemalnutritionsarcopeniasupplementation

Identifiers

PMID27187465
PMCPMC4882708
OpenAlexW2375517807

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.