Evidence map›Paper›PMID 27187235›Full record

ArticleTranslational psychiatry2016

The NADPH oxidase NOX2 as a novel biomarker for suicidality: evidence from human post mortem brain samples.

S Schiavone, M Neri, E Mhillaj, M G Morgese, S Cantatore, M Bove, I Riezzo, P Tucci, C Pomara, E Turillazzi and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Alterations of pro- and anti-inflammatory cytokines balance and superoxide dismutase in the dorsolateral prefrontal cortex of suicide decedents.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
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  7. Advances in Technologies in Crime Scene Investigation.Diagnostics (Basel, Switzerland) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

S SchiavoneDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
M NeriDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
E MhillajDepartment of Physiology and Pharmacology, 'Sapienza' University of Rome, Rome, Italy.
M G MorgeseDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
S CantatoreDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
M BoveDepartment of Physiology and Pharmacology, 'Sapienza' University of Rome, Rome, Italy.
I RiezzoDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
P TucciDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
C PomaraDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
E TurillazziDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
V CuomoDepartment of Physiology and Pharmacology, 'Sapienza' University of Rome, Rome, Italy.
L TrabaceDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
University of Foggia · ITSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent evidence points towards a role of oxidative stress in suicidality. However, few studies were carried out on the sources of reactive oxygen species (ROS) in subjects with suicidal behaviour. We have previously demonstrated that the NADPH oxidase NOX2-derived oxidative stress has a major role in the development of neuropathological alterations observed in an animal model of psychosis. Here, we investigated the possible increase in NOX2 in post mortem brain samples of subjects who died by asphyctic suicide (AS) compared with controls (CTRL) and subjects who died by non-suicidal asphyxia (NSA). We found that NOX2 expression was significantly higher in the cortex of AS subjects than in the other two experimental groups. NOX2 immunostaining was mainly detected in GABAergic neurons, with a minor presence of NOX2-positive-stained cells in glutamatergic and dopaminergic neurons, as well as astrocytes and microglia. A sustained increase in the expression of 8-hydroxy-2'-deoxyguanosine, an indirect marker of oxidative stress, was also detected in the cortex of AS subjects, compared with CTRL and NSA subjects. A significant elevation in cortical interleukin-6 immunoreactivity in AS subjects suggested an involvement of cytokine-associated molecular pathways in NOX2 elevations. Our results suggest that the increase in NOX2-derived oxidative stress in the brain might be involved in the neuropathological pathways leading to suicidal behaviour. These results may open innovative insights in the identification of new pathogenetic and necroscopic biomarkers, predictive for suicidality and potentially useful for suicide prevention.

Indexed as

Oxidative StressSuicideAdolescentAdultAgedAsphyxiaAstrocytesAutopsyBrainCase-Control StudiesDopaminergic NeuronsFemaleGlutamic AcidHumansInterleukin-6MaleCYBB protein, humanGlutamic AcidIL6 protein, humanInterleukin-6NADPH Oxidase 2

Identifiers

PMID27187235
PMCPMC5070044
OpenAlexW2398820487

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.