ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2016
Neuronal Allocation to a Hippocampal Engram.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.
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Who cites it
102 citing papers in PubMed, 188 citations in OpenAlex.
- ICER-Controlled inhibitory plasticity of amygdala engram neurons regulates fear memory precision.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Intrinsic Excitability of Rat Hippocampal Granule Cells Increases Along the Dorsal-to-Ventral Axis.Hippocampus · 2026Article
- Molecular architects of memory: BDNF/TrkB signaling and trafficking in neuronal plasticity and memory.Molecular psychiatry · 2026Review
- NongeneticACS nano · 2026Article
- Old mice fail to integrate a memory update into an existing hippocampal engram.bioRxiv : the preprint server for biology · 2026Article
- CA1 Engram Cell Dynamics Before and After Learning.bioRxiv : the preprint server for biology · 2026Article
- Dentate Gyrus Engrams in Fear and Reward: Mechanistic Principles, Critical Gaps, and Paths to Translation.Journal of neurochemistry · 2026Review
- Rodents' episodic-like memory: concepts, ageing, neurodegeneration, future.Translational neuroscience · 2026Article
- Writing the Engram: Epigenetic Mechanisms of Memory Allocation.Journal of neurochemistry · 2025Review
- Neuronal allocation and sparse coding of episodic memories in the human hippocampus.Scientific reports · 2025Article
- Adverse gestational environment configures a subpopulation of ventral dentate granule cells for recruitment to drive innate anxiety.Cell reports · 2025Article
- Degeneracy Explains Diversity in Interneuronal Regulation of Pattern Separation in Heterogeneous Dentate Gyrus Networks.Function (Oxford, England) · 2025Article
- Cocaine-context memories are transcriptionally encoded in nucleus accumbens Arc ensembles.Nature communications · 2025Article
- Memory processing by hippocampal adult-born neurons.Neurobiology of learning and memory · 2025Review
- Parallel processing of past and future memories through reactivation and synaptic plasticity mechanisms during sleep.Nature communications · 2025Article
- Brain-wide immunolabeling and tissue clearing applications for engram research.Neurobiology of learning and memory · 2025Review
- Higher-order interactions between hippocampal CA1 neurons are disrupted in amnestic mice.Nature neuroscience · 2024Article
- Comparing behaviours induced by natural memory retrieval and optogenetic reactivation of an engram ensemble in mice.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Phospholipase C beta 1 in the dentate gyrus gates fear memory formation through regulation of neuronal excitability.Science advances · 2024Article
- Reactivation of encoding ensembles in the prelimbic cortex supports temporal associations.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
42 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The dentate gyrus (DG) is important for encoding contextual memories, but little is known about how a population of DG neurons comes to encode and support a particular memory. One possibility is that recruitment into an engram depends on a neuron's excitability. Here, we manipulated excitability by overexpressing CREB in a random population of DG neurons and examined whether this biased their recruitment to an engram supporting a contextual fear memory. To directly assess whether neurons overexpressing CREB at the time of training became critical components of the engram, we examined memory expression while the activity of these neurons was silenced. Chemogenetically (hM4Di, an inhibitory DREADD receptor) or optogenetically (iC++, a light-activated chloride channel) silencing the small number of CREB-overexpressing DG neurons attenuated memory expression, whereas silencing a similar number of random neurons not overexpressing CREB at the time of training did not. As post-encoding reactivation of the activity patterns present during initial experience is thought to be important in memory consolidation, we investigated whether post-training silencing of neurons allocated to an engram disrupted subsequent memory expression. We found that silencing neurons 5 min (but not 24 h) following training disrupted memory expression. Together these results indicate that the rules of neuronal allocation to an engram originally described in the lateral amygdala are followed in different brain regions including DG, and moreover, that disrupting the post-training activity pattern of these neurons prevents memory consolidation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.