Evidence map›Paper›PMID 27186939›Full record

ArticleNeuromodulation : journal of the International Neuromodulation Society2016

A Pilot Study Assessing the Effects of Pallidal Deep Brain Stimulation on Sleep Quality and Polysomnography in Parkinson's Patients.

Christopher M Tolleson, Kanika Bagai, Arthur S Walters, Thomas L Davis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuromodulation : journal of the International Neuromodulation Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. The effects of deep brain stimulation on sleep: a systematic review and meta-analysis.Sleep advances : a journal of the Sleep Research Society · 2024
    Review
  7. Article
  8. Insomnia in neurological diseases.Neurological research and practice · 2021
    Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Christopher M TollesonDepartment of Neurology, Movement Disorders Division, Vanderbilt University, Nashville, TN, USA. christopher.tolleson@vanderbilt.edu.
Kanika BagaiDepartment of Neurology, Sleep Division, Vanderbilt University, Nashville, TN, USA.
Arthur S WaltersDepartment of Neurology, Sleep Division, Vanderbilt University, Nashville, TN, USA.
Thomas L DavisDepartment of Neurology, Movement Disorders Division, Vanderbilt University, Nashville, TN, USA.

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Computer-Assisted functional neurosurgeryR01EB006136 · NIBIB · VANDERBILT UNIVERSITY · PI DAWANT, BENOIT M. · 2006 to 2013
$4.0M
Computer-Assited Functional NeurosurgeryR01NS095291 · NINDS · VANDERBILT UNIVERSITY · PI DAWANT, BENOIT M., DHAESE, PIERRE F. · 2015 to 2018
$2.4M
NCATS NIH HHS UL1 TR000445NIBIB NIH HHS R01 EB006136NINDS NIH HHS R01 NS095291
6 · The paper itself

Abstract

objectiveDeep Brain Stimulation (DBS) is an established adjunctive surgical intervention to treat poorly controlled motor symptoms in Parkinson's disease (PD). Both surgical targets (the subthalamic nucleus and globus pallidus) have proven equally efficacious in treating motor symptoms but unique differences may exist in effects on nonmotor symptoms. Sleep dysfunction, a common disabling symptom in PD, has only been examined directly in the subthalamic target, demonstrating some beneficial changes in sleep quality. We aimed to explore sleep changes after pallidal stimulation; hypothesizing similar benefits would be seen.

methodsWe performed a prospective nonblinded clinical trial evaluating sleep in five PD patients already slated for pallidal DBS pre and six months postimplantation using validated sleep surveys and polysomnograms (PSGs). Surveys included the Epworth sleepiness scale, PD sleep scale, Insomnia severity index (ISI), and RLS severity scale.

resultsMost patients had notable improvements in sleep quality as measured by PSG metrics such as sleep efficiency and latency to sleep but they did not reach statistical significance. Most surveys reflected an improvement as well with the ISI scale showing the most promising trend post pallidal DBS (14.4 ± 7.02 vs. 9.0 ± 2.55; p = 0.07).

conclusionIn this small pilot trial, pallidal DBS failed to demonstrate statistically significant improvements in sleep metrics postimplantation but did reveal improving trends in several PSG measures including sleep efficiency and latency to sleep onset as well as sleep survey scores. A larger, blinded clinical trial is needed to more definitively determine whether pallidal DBS may benefit sleep.

Indexed as

Treatment OutcomeAgedDeep Brain StimulationFemaleGlobus PallidusHumansMaleMiddle AgedParkinson DiseasePilot ProjectsPolysomnographySleep Wake Disordersdeep brain stimulationglobus pallidusParkinson's diseasesleep

Identifiers

PMID27186939
PMCPMC5053840

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.