Trial reportThe Journal of clinical endocrinology and metabolism2016
Vitamin D Status Relates to Reproductive Outcome in Women With Polycystic Ovary Syndrome: Secondary Analysis of a Multicenter Randomized Controlled Trial.
Registry-linked trialOpen access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph
Trial report in The Journal of clinical endocrinology and metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03792984 (The Effect of Calcium and Vitamin D Supplements as an Adjuvant Therapy to Metformin on Metabolic and Hormonal Disturbances in Polycystic Ovary Syndrome Patients), which is not on this map. Cited by 42 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 2 pooled it
15.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Calcium and Vitamin D Supplements as an Adjuvant Therapy to Metformin on Metabolic and Hormonal Disturbances in Polycystic Ovary Syndrome Patients
Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 98 citations in OpenAlex.
- Antioxidants for female subfertility.The Cochrane database of systematic reviews · 2020Pooled it
- Antioxidants for female subfertility.The Cochrane database of systematic reviews · 2017Pooled it
- Vitamin D supplementation before in vitro fertilisation in women with polycystic ovary syndrome: multicentre, double blind, placebo controlled, randomised clinical trial.BMJ (Clinical research ed.) · 2026Trial
- Effects of Vitamin D3 Treatment on Polycystic Ovary Symptoms: A Prospective Double-Blind Two-Phase Randomized Controlled Clinical Trial.Nutrients · 2025Trial
- Male vitamin D status and male factor infertility.Fertility and sterility · 2021Trial
- Trial
- Vitamin D in Endocrine Disorders: A Broad Overview of Evidence in Musculoskeletal, Thyroid, Parathyroid, and Reproductive Disorders.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Reducing Storage-Related Bias in Reproductive Vitamin D Research: Towards a Stable and Reliable Biomarker of Ovarian Vitamin D Status.Nutrients · 2025Article
- Impact of vitamin D deficiency on defective endometrial decidualization and the repressive role of vitamin D receptor (VDR) in the epigenomic network.bioRxiv : the preprint server for biology · 2025Article
- Vitamin D in Reproductive Health Disorders: A Narrative Review Focusing on Infertility, Endometriosis, and Polycystic Ovarian Syndrome.International journal of molecular sciences · 2025Review
- Association of serum vitamin D level and live birth rate in women undergoing frozen embryo transfer-a retrospective cohort study.Journal of assisted reproduction and genetics · 2025Article
- Effect of vitamin D deficiency on clinical pregnancy outcomes in women with polycystic ovary syndrome undergoingFrontiers in endocrinology · 2025Article
- Nutritional Interventions for Enhancing Female Fertility: A Comprehensive Review of Micronutrients and Their Impact.Nursing research and practice · 2025Review
- Article
- Women's fertility and vitamin D: Could hypovitaminosis D biomarkers correlate with the disease, and explain the unexplained female factor infertility?African health sciences · 2024Article
- Review
- [Resolution of the national interdisciplinary council of experts "High-dose vitamin D (Devilam) in the practice of an obstetrician-gynecologist"].Problemy endokrinologii · 2024Article
- Causal association between low vitamin D and polycystic ovary syndrome: a bidirectional mendelian randomization study.Journal of ovarian research · 2024Article
- Article
- Association between serum 25-hydroxyvitamin D and antimüllerian hormone levels in a cohort of African-American women.Fertility and sterility · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 5 institutions in 1 country.
Lubna PalDepartment of Obstetrics, Gynecology, and Reproductive Sciences (L.P., H.Z., J.W.), Yale School of Medicine, New Haven, Connecticut 06510; Department of Obstetrics and Gynecology (N.F.S., W.D.S.), University of Colorado, Denver, Colorado 80238; Department of Obstetrics and Gynecology (M.P.D.), Georgia Regents University, Augusta, Georgia 30912; Department of Obstetrics and Gynecology (C.C.), University of Pennsylvania, Philadelphia, Pennsylvania 19104; Baylor College of Medicine (S.A.C.), Houston, Texas 77030; University of Alabama (M.P.S.), Birmingham, Alabama 35233; University of Texas Southwestern Medical Center (B.R.C.), Dallas, Texas 75390; University of Medicine and Dentistry of New Jersey (P.G.M.), Newark, New Jersey 07103; Stanford University (N.A.C.), Stanford, California 94305; University of Pittsburgh (G.G.G.), Pittsburgh, Pennsylvania 15206; Department of Medicine (J.E.N.), Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298; Department of Obstetrics and Gynecology and Duke Clinical Research Institute (E.M.), Duke University Medical Center, Durham North Carolina 27710; and Department of Obstetrics and Gynecology (R.S.L.), Penn State College of Medicine, Hershey, Pennsylvania 17033.
Heping ZhangDepartment of Obstetrics, Gynecology, and Reproductive Sciences (L.P., H.Z., J.W.), Yale School of Medicine, New Haven, Connecticut 06510; Department of Obstetrics and Gynecology (N.F.S., W.D.S.), University of Colorado, Denver, Colorado 80238; Department of Obstetrics and Gynecology (M.P.D.), Georgia Regents University, Augusta, Georgia 30912; Department of Obstetrics and Gynecology (C.C.), University of Pennsylvania, Philadelphia, Pennsylvania 19104; Baylor College of Medicine (S.A.C.), Houston, Texas 77030; University of Alabama (M.P.S.), Birmingham, Alabama 35233; University of Texas Southwestern Medical Center (B.R.C.), Dallas, Texas 75390; University of Medicine and Dentistry of New Jersey (P.G.M.), Newark, New Jersey 07103; Stanford University (N.A.C.), Stanford, California 94305; University of Pittsburgh (G.G.G.), Pittsburgh, Pennsylvania 15206; Department of Medicine (J.E.N.), Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298; Department of Obstetrics and Gynecology and Duke Clinical Research Institute (E.M.), Duke University Medical Center, Durham North Carolina 27710; and Department of Obstetrics and Gynecology (R.S.L.), Penn State College of Medicine, Hershey, Pennsylvania 17033.
Joanne WilliamsDepartment of Obstetrics, Gynecology, and Reproductive Sciences (L.P., H.Z., J.W.), Yale School of Medicine, New Haven, Connecticut 06510; Department of Obstetrics and Gynecology (N.F.S., W.D.S.), University of Colorado, Denver, Colorado 80238; Department of Obstetrics and Gynecology (M.P.D.), Georgia Regents University, Augusta, Georgia 30912; Department of Obstetrics and Gynecology (C.C.), University of Pennsylvania, Philadelphia, Pennsylvania 19104; Baylor College of Medicine (S.A.C.), Houston, Texas 77030; University of Alabama (M.P.S.), Birmingham, Alabama 35233; University of Texas Southwestern Medical Center (B.R.C.), Dallas, Texas 75390; University of Medicine and Dentistry of New Jersey (P.G.M.), Newark, New Jersey 07103; Stanford University (N.A.C.), Stanford, California 94305; University of Pittsburgh (G.G.G.), Pittsburgh, Pennsylvania 15206; Department of Medicine (J.E.N.), Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298; Department of Obstetrics and Gynecology and Duke Clinical Research Institute (E.M.), Duke University Medical Center, Durham North Carolina 27710; and Department of Obstetrics and Gynecology (R.S.L.), Penn State College of Medicine, Hershey, Pennsylvania 17033.
Nanette F SantoroDepartment of Obstetrics, Gynecology, and Reproductive Sciences (L.P., H.Z., J.W.), Yale School of Medicine, New Haven, Connecticut 06510; Department of Obstetrics and Gynecology (N.F.S., W.D.S.), University of Colorado, Denver, Colorado 80238; Department of Obstetrics and Gynecology (M.P.D.), Georgia Regents University, Augusta, Georgia 30912; Department of Obstetrics and Gynecology (C.C.), University of Pennsylvania, Philadelphia, Pennsylvania 19104; Baylor College of Medicine (S.A.C.), Houston, Texas 77030; University of Alabama (M.P.S.), Birmingham, Alabama 35233; University of Texas Southwestern Medical Center (B.R.C.), Dallas, Texas 75390; University of Medicine and Dentistry of New Jersey (P.G.M.), Newark, New Jersey 07103; Stanford University (N.A.C.), Stanford, California 94305; University of Pittsburgh (G.G.G.), Pittsburgh, Pennsylvania 15206; Department of Medicine (J.E.N.), Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298; Department of Obstetrics and Gynecology and Duke Clinical Research Institute (E.M.), Duke University Medical Center, Durham North Carolina 27710; and Department of Obstetrics and Gynecology (R.S.L.), Penn State College of Medicine, Hershey, Pennsylvania 17033.
Michael P DiamondDepartment of Obstetrics, Gynecology, and Reproductive Sciences (L.P., H.Z., J.W.), Yale School of Medicine, New Haven, Connecticut 06510; Department of Obstetrics and Gynecology (N.F.S., W.D.S.), University of Colorado, Denver, Colorado 80238; Department of Obstetrics and Gynecology (M.P.D.), Georgia Regents University, Augusta, Georgia 30912; Department of Obstetrics and Gynecology (C.C.), University of Pennsylvania, Philadelphia, Pennsylvania 19104; Baylor College of Medicine (S.A.C.), Houston, Texas 77030; University of Alabama (M.P.S.), Birmingham, Alabama 35233; University of Texas Southwestern Medical Center (B.R.C.), Dallas, Texas 75390; University of Medicine and Dentistry of New Jersey (P.G.M.), Newark, New Jersey 07103; Stanford University (N.A.C.), Stanford, California 94305; University of Pittsburgh (G.G.G.), Pittsburgh, Pennsylvania 15206; Department of Medicine (J.E.N.), Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298; Department of Obstetrics and Gynecology and Duke Clinical Research Institute (E.M.), Duke University Medical Center, Durham North Carolina 27710; and Department of Obstetrics and Gynecology (R.S.L.), Penn State College of Medicine, Hershey, Pennsylvania 17033.
William D SchlaffDepartment of Obstetrics, Gynecology, and Reproductive Sciences (L.P., H.Z., J.W.), Yale School of Medicine, New Haven, Connecticut 06510; Department of Obstetrics and Gynecology (N.F.S., W.D.S.), University of Colorado, Denver, Colorado 80238; Department of Obstetrics and Gynecology (M.P.D.), Georgia Regents University, Augusta, Georgia 30912; Department of Obstetrics and Gynecology (C.C.), University of Pennsylvania, Philadelphia, Pennsylvania 19104; Baylor College of Medicine (S.A.C.), Houston, Texas 77030; University of Alabama (M.P.S.), Birmingham, Alabama 35233; University of Texas Southwestern Medical Center (B.R.C.), Dallas, Texas 75390; University of Medicine and Dentistry of New Jersey (P.G.M.), Newark, New Jersey 07103; Stanford University (N.A.C.), Stanford, California 94305; University of Pittsburgh (G.G.G.), Pittsburgh, Pennsylvania 15206; Department of Medicine (J.E.N.), Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298; Department of Obstetrics and Gynecology and Duke Clinical Research Institute (E.M.), Duke University Medical Center, Durham North Carolina 27710; and Department of Obstetrics and Gynecology (R.S.L.), Penn State College of Medicine, Hershey, Pennsylvania 17033.
Christos CoutifarisDepartment of Obstetrics, Gynecology, and Reproductive Sciences (L.P., H.Z., J.W.), Yale School of Medicine, New Haven, Connecticut 06510; Department of Obstetrics and Gynecology (N.F.S., W.D.S.), University of Colorado, Denver, Colorado 80238; Department of Obstetrics and Gynecology (M.P.D.), Georgia Regents University, Augusta, Georgia 30912; Department of Obstetrics and Gynecology (C.C.), University of Pennsylvania, Philadelphia, Pennsylvania 19104; Baylor College of Medicine (S.A.C.), Houston, Texas 77030; University of Alabama (M.P.S.), Birmingham, Alabama 35233; University of Texas Southwestern Medical Center (B.R.C.), Dallas, Texas 75390; University of Medicine and Dentistry of New Jersey (P.G.M.), Newark, New Jersey 07103; Stanford University (N.A.C.), Stanford, California 94305; University of Pittsburgh (G.G.G.), Pittsburgh, Pennsylvania 15206; Department of Medicine (J.E.N.), Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298; Department of Obstetrics and Gynecology and Duke Clinical Research Institute (E.M.), Duke University Medical Center, Durham North Carolina 27710; and Department of Obstetrics and Gynecology (R.S.L.), Penn State College of Medicine, Hershey, Pennsylvania 17033.
Sandra A CarsonDepartment of Obstetrics, Gynecology, and Reproductive Sciences (L.P., H.Z., J.W.), Yale School of Medicine, New Haven, Connecticut 06510; Department of Obstetrics and Gynecology (N.F.S., W.D.S.), University of Colorado, Denver, Colorado 80238; Department of Obstetrics and Gynecology (M.P.D.), Georgia Regents University, Augusta, Georgia 30912; Department of Obstetrics and Gynecology (C.C.), University of Pennsylvania, Philadelphia, Pennsylvania 19104; Baylor College of Medicine (S.A.C.), Houston, Texas 77030; University of Alabama (M.P.S.), Birmingham, Alabama 35233; University of Texas Southwestern Medical Center (B.R.C.), Dallas, Texas 75390; University of Medicine and Dentistry of New Jersey (P.G.M.), Newark, New Jersey 07103; Stanford University (N.A.C.), Stanford, California 94305; University of Pittsburgh (G.G.G.), Pittsburgh, Pennsylvania 15206; Department of Medicine (J.E.N.), Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298; Department of Obstetrics and Gynecology and Duke Clinical Research Institute (E.M.), Duke University Medical Center, Durham North Carolina 27710; and Department of Obstetrics and Gynecology (R.S.L.), Penn State College of Medicine, Hershey, Pennsylvania 17033.
Michael P SteinkampfDepartment of Obstetrics, Gynecology, and Reproductive Sciences (L.P., H.Z., J.W.), Yale School of Medicine, New Haven, Connecticut 06510; Department of Obstetrics and Gynecology (N.F.S., W.D.S.), University of Colorado, Denver, Colorado 80238; Department of Obstetrics and Gynecology (M.P.D.), Georgia Regents University, Augusta, Georgia 30912; Department of Obstetrics and Gynecology (C.C.), University of Pennsylvania, Philadelphia, Pennsylvania 19104; Baylor College of Medicine (S.A.C.), Houston, Texas 77030; University of Alabama (M.P.S.), Birmingham, Alabama 35233; University of Texas Southwestern Medical Center (B.R.C.), Dallas, Texas 75390; University of Medicine and Dentistry of New Jersey (P.G.M.), Newark, New Jersey 07103; Stanford University (N.A.C.), Stanford, California 94305; University of Pittsburgh (G.G.G.), Pittsburgh, Pennsylvania 15206; Department of Medicine (J.E.N.), Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298; Department of Obstetrics and Gynecology and Duke Clinical Research Institute (E.M.), Duke University Medical Center, Durham North Carolina 27710; and Department of Obstetrics and Gynecology (R.S.L.), Penn State College of Medicine, Hershey, Pennsylvania 17033.
Bruce R CarrDepartment of Obstetrics, Gynecology, and Reproductive Sciences (L.P., H.Z., J.W.), Yale School of Medicine, New Haven, Connecticut 06510; Department of Obstetrics and Gynecology (N.F.S., W.D.S.), University of Colorado, Denver, Colorado 80238; Department of Obstetrics and Gynecology (M.P.D.), Georgia Regents University, Augusta, Georgia 30912; Department of Obstetrics and Gynecology (C.C.), University of Pennsylvania, Philadelphia, Pennsylvania 19104; Baylor College of Medicine (S.A.C.), Houston, Texas 77030; University of Alabama (M.P.S.), Birmingham, Alabama 35233; University of Texas Southwestern Medical Center (B.R.C.), Dallas, Texas 75390; University of Medicine and Dentistry of New Jersey (P.G.M.), Newark, New Jersey 07103; Stanford University (N.A.C.), Stanford, California 94305; University of Pittsburgh (G.G.G.), Pittsburgh, Pennsylvania 15206; Department of Medicine (J.E.N.), Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298; Department of Obstetrics and Gynecology and Duke Clinical Research Institute (E.M.), Duke University Medical Center, Durham North Carolina 27710; and Department of Obstetrics and Gynecology (R.S.L.), Penn State College of Medicine, Hershey, Pennsylvania 17033.
Peter G McGovernDepartment of Obstetrics, Gynecology, and Reproductive Sciences (L.P., H.Z., J.W.), Yale School of Medicine, New Haven, Connecticut 06510; Department of Obstetrics and Gynecology (N.F.S., W.D.S.), University of Colorado, Denver, Colorado 80238; Department of Obstetrics and Gynecology (M.P.D.), Georgia Regents University, Augusta, Georgia 30912; Department of Obstetrics and Gynecology (C.C.), University of Pennsylvania, Philadelphia, Pennsylvania 19104; Baylor College of Medicine (S.A.C.), Houston, Texas 77030; University of Alabama (M.P.S.), Birmingham, Alabama 35233; University of Texas Southwestern Medical Center (B.R.C.), Dallas, Texas 75390; University of Medicine and Dentistry of New Jersey (P.G.M.), Newark, New Jersey 07103; Stanford University (N.A.C.), Stanford, California 94305; University of Pittsburgh (G.G.G.), Pittsburgh, Pennsylvania 15206; Department of Medicine (J.E.N.), Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298; Department of Obstetrics and Gynecology and Duke Clinical Research Institute (E.M.), Duke University Medical Center, Durham North Carolina 27710; and Department of Obstetrics and Gynecology (R.S.L.), Penn State College of Medicine, Hershey, Pennsylvania 17033.
Nicholas A CataldoDepartment of Obstetrics, Gynecology, and Reproductive Sciences (L.P., H.Z., J.W.), Yale School of Medicine, New Haven, Connecticut 06510; Department of Obstetrics and Gynecology (N.F.S., W.D.S.), University of Colorado, Denver, Colorado 80238; Department of Obstetrics and Gynecology (M.P.D.), Georgia Regents University, Augusta, Georgia 30912; Department of Obstetrics and Gynecology (C.C.), University of Pennsylvania, Philadelphia, Pennsylvania 19104; Baylor College of Medicine (S.A.C.), Houston, Texas 77030; University of Alabama (M.P.S.), Birmingham, Alabama 35233; University of Texas Southwestern Medical Center (B.R.C.), Dallas, Texas 75390; University of Medicine and Dentistry of New Jersey (P.G.M.), Newark, New Jersey 07103; Stanford University (N.A.C.), Stanford, California 94305; University of Pittsburgh (G.G.G.), Pittsburgh, Pennsylvania 15206; Department of Medicine (J.E.N.), Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298; Department of Obstetrics and Gynecology and Duke Clinical Research Institute (E.M.), Duke University Medical Center, Durham North Carolina 27710; and Department of Obstetrics and Gynecology (R.S.L.), Penn State College of Medicine, Hershey, Pennsylvania 17033.
Gabriella G GosmanDepartment of Obstetrics, Gynecology, and Reproductive Sciences (L.P., H.Z., J.W.), Yale School of Medicine, New Haven, Connecticut 06510; Department of Obstetrics and Gynecology (N.F.S., W.D.S.), University of Colorado, Denver, Colorado 80238; Department of Obstetrics and Gynecology (M.P.D.), Georgia Regents University, Augusta, Georgia 30912; Department of Obstetrics and Gynecology (C.C.), University of Pennsylvania, Philadelphia, Pennsylvania 19104; Baylor College of Medicine (S.A.C.), Houston, Texas 77030; University of Alabama (M.P.S.), Birmingham, Alabama 35233; University of Texas Southwestern Medical Center (B.R.C.), Dallas, Texas 75390; University of Medicine and Dentistry of New Jersey (P.G.M.), Newark, New Jersey 07103; Stanford University (N.A.C.), Stanford, California 94305; University of Pittsburgh (G.G.G.), Pittsburgh, Pennsylvania 15206; Department of Medicine (J.E.N.), Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298; Department of Obstetrics and Gynecology and Duke Clinical Research Institute (E.M.), Duke University Medical Center, Durham North Carolina 27710; and Department of Obstetrics and Gynecology (R.S.L.), Penn State College of Medicine, Hershey, Pennsylvania 17033.
John E NestlerDepartment of Obstetrics, Gynecology, and Reproductive Sciences (L.P., H.Z., J.W.), Yale School of Medicine, New Haven, Connecticut 06510; Department of Obstetrics and Gynecology (N.F.S., W.D.S.), University of Colorado, Denver, Colorado 80238; Department of Obstetrics and Gynecology (M.P.D.), Georgia Regents University, Augusta, Georgia 30912; Department of Obstetrics and Gynecology (C.C.), University of Pennsylvania, Philadelphia, Pennsylvania 19104; Baylor College of Medicine (S.A.C.), Houston, Texas 77030; University of Alabama (M.P.S.), Birmingham, Alabama 35233; University of Texas Southwestern Medical Center (B.R.C.), Dallas, Texas 75390; University of Medicine and Dentistry of New Jersey (P.G.M.), Newark, New Jersey 07103; Stanford University (N.A.C.), Stanford, California 94305; University of Pittsburgh (G.G.G.), Pittsburgh, Pennsylvania 15206; Department of Medicine (J.E.N.), Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298; Department of Obstetrics and Gynecology and Duke Clinical Research Institute (E.M.), Duke University Medical Center, Durham North Carolina 27710; and Department of Obstetrics and Gynecology (R.S.L.), Penn State College of Medicine, Hershey, Pennsylvania 17033.
Evan MyersDepartment of Obstetrics, Gynecology, and Reproductive Sciences (L.P., H.Z., J.W.), Yale School of Medicine, New Haven, Connecticut 06510; Department of Obstetrics and Gynecology (N.F.S., W.D.S.), University of Colorado, Denver, Colorado 80238; Department of Obstetrics and Gynecology (M.P.D.), Georgia Regents University, Augusta, Georgia 30912; Department of Obstetrics and Gynecology (C.C.), University of Pennsylvania, Philadelphia, Pennsylvania 19104; Baylor College of Medicine (S.A.C.), Houston, Texas 77030; University of Alabama (M.P.S.), Birmingham, Alabama 35233; University of Texas Southwestern Medical Center (B.R.C.), Dallas, Texas 75390; University of Medicine and Dentistry of New Jersey (P.G.M.), Newark, New Jersey 07103; Stanford University (N.A.C.), Stanford, California 94305; University of Pittsburgh (G.G.G.), Pittsburgh, Pennsylvania 15206; Department of Medicine (J.E.N.), Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298; Department of Obstetrics and Gynecology and Duke Clinical Research Institute (E.M.), Duke University Medical Center, Durham North Carolina 27710; and Department of Obstetrics and Gynecology (R.S.L.), Penn State College of Medicine, Hershey, Pennsylvania 17033.
Richard S LegroDepartment of Obstetrics, Gynecology, and Reproductive Sciences (L.P., H.Z., J.W.), Yale School of Medicine, New Haven, Connecticut 06510; Department of Obstetrics and Gynecology (N.F.S., W.D.S.), University of Colorado, Denver, Colorado 80238; Department of Obstetrics and Gynecology (M.P.D.), Georgia Regents University, Augusta, Georgia 30912; Department of Obstetrics and Gynecology (C.C.), University of Pennsylvania, Philadelphia, Pennsylvania 19104; Baylor College of Medicine (S.A.C.), Houston, Texas 77030; University of Alabama (M.P.S.), Birmingham, Alabama 35233; University of Texas Southwestern Medical Center (B.R.C.), Dallas, Texas 75390; University of Medicine and Dentistry of New Jersey (P.G.M.), Newark, New Jersey 07103; Stanford University (N.A.C.), Stanford, California 94305; University of Pittsburgh (G.G.G.), Pittsburgh, Pennsylvania 15206; Department of Medicine (J.E.N.), Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298; Department of Obstetrics and Gynecology and Duke Clinical Research Institute (E.M.), Duke University Medical Center, Durham North Carolina 27710; and Department of Obstetrics and Gynecology (R.S.L.), Penn State College of Medicine, Hershey, Pennsylvania 17033.
Reproductive Medicine Network
Augusta University · USYale University · USBaylor College of Medicine · USGeorgia Regents Medical Center · USThe University of Texas Southwestern Medical Center · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MYALE UNIVERSITY CLINICAL AND TRANSLATIONAL SCIENCE AWARD PROGRAMUL1RR024139 · NCRR · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2006 to 2011
$56.8MData Coordination Center for the RMNU10HD055925 · NICHD · YALE UNIVERSITY · PI ZHANG, HEPING · 2007 to 2019
$39.2MPILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Edward L Melanson · 1995 to 2026
$32.6MWITHIN SUBJ VARIABILITY IN MEASUREMENTS DRUG METABOL ENZYMES IN HLTY SUBJM01RR000056 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEVINE, ARTHUR S · 1985 to 2006
$29.2MCOOPERATIVE MULTICENTER REPRODUCTIVE MEDICINE NETWORKU10HD027049 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI COUTIFARIS, CHRISTOS · 1990 to 2017
$5.2MGHSU/WSU Cooperative Reproductive Medicine NetworkU10HD039005 · NICHD · WAYNE STATE UNIVERSITY · PI DIAMOND, MICHAEL PETER · 2000 to 2017
$5.2MCOOPERATIVE MULTICENTER REPRODUCTIVE MEDICINE NETWORKU10HD038992 · NICHD · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI LEGRO, RICHARD S. · 2000 to 2017
$5.0MCOOPERATIVE MULTICENTER REPRODUCTIVE MEDICINE NETWORKU10HD038998 · NICHD · UNIVERSITY OF COLORADO DENVER · PI POLOTSKY, ALEX JOEL · 2000 to 2015
$2.6MCooperative Multicenter Reproductive Medicine Network (U10)U10HD055936 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SMITH, YOLANDA R · 2007 to 2014
$2.1MNCATS NIH HHS UL1 TR001863NCRR NIH HHS M01 RR000056NCRR NIH HHS UL1 RR024139NICHD NIH HHS U10 HD027049NICHD NIH HHS U10 HD038992NICHD NIH HHS U10 HD038998NICHD NIH HHS U10 HD039005NICHD NIH HHS U10 HD055925NICHD NIH HHS U10 HD055936
Abstract
contextExperimental evidence supports a relevance of vitamin D (VitD) for reproduction; however, data in humans are sparse and inconsistent.
objectiveTo assess the relationship of VitD status with ovulation induction (OI) outcomes in women with polycystic ovary syndrome (PCOS).
designA retrospective cohort.
settingSecondary analysis of randomized controlled trial data.
participantsParticipants in the Pregnancy in PCOS I (PPCOS I) randomized controlled trial (n = 540) met the National Institutes of Health diagnostic criteria for PCOS.
interventionsSerum 25OHD levels were measured in stored sera.
main outcome measuresPrimary, live birth (LB); secondary, ovulation and pregnancy loss after OI.
resultsLikelihood for LB was reduced by 44% for women if the 25OHD level was < 30 ng/mL (<75 nmol/L; odds ratio [OR], 0.58 [0.35-0.92]). Progressive improvement in the odds for LB was noted at thresholds of ≥38 ng/mL (≥95 nmol/L; OR, 1.42 [1.08-1.8]), ≥40 ng/mL (≥100 nmol/L; OR, 1.51 [1.05-2.17]), and ≥45 ng/mL (≥112.5 nmol/L; OR, 4.46 [1.27-15.72]). On adjusted analyses, VitD status was an independent predictor of LB and ovulation after OI.
conclusionsIn women with PCOS, serum 25OHD was an independent predictor of measures of reproductive success after OI. Our data identify reproductive thresholds for serum 25OHD that are higher than recommended for the nonpregnant population.
Indexed as
AdolescentAdultFemaleFertility Agents, FemaleHumansInfertility, FemaleOvulation InductionPolycystic Ovary SyndromePregnancyPregnancy RatePrognosisTreatment OutcomeVitamin DYoung AdultFertility Agents, FemaleVitamin D
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NCT03792984ClinicalTrials.gov
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